US 11,933,710 B2
3D particle imaging
Wim De Malsche, Berchem (BE); Ozlem Sardan Sukas, Eindhoven (NL); Manly Callewaert, Ledeberg (BE); and Pierre Gelin, Wemmel (BE)
Assigned to VRIJE UNIVERSITEIT BRUSSEL, Brussels (BE)
Appl. No. 17/047,998
Filed by VRIJE UNIVERSITEIT BRUSSEL, Brussels (BE)
PCT Filed Apr. 17, 2019, PCT No. PCT/EP2019/059953
§ 371(c)(1), (2) Date Oct. 15, 2020,
PCT Pub. No. WO2019/202007, PCT Pub. Date Oct. 24, 2019.
Claims priority of application No. 18167868 (EP), filed on Apr. 17, 2018.
Prior Publication US 2021/0140869 A1, May 13, 2021
Int. Cl. G02B 21/16 (2006.01); G01N 15/14 (2006.01); G01P 5/00 (2006.01); G02B 21/26 (2006.01); G02B 21/36 (2006.01); G01N 15/00 (2006.01); G01N 15/10 (2006.01)
CPC G01N 15/147 (2013.01) [G01N 15/1434 (2013.01); G01P 5/001 (2013.01); G02B 21/16 (2013.01); G02B 21/26 (2013.01); G02B 21/365 (2013.01); G01N 2015/0053 (2013.01); G01N 2015/1075 (2013.01); G01N 2015/1445 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A system for imaging particles in a fluid, the system comprising:
a substrate holder for holding a substrate comprising a channel or reservoir for containing the fluid in the substrate,
a radiation source for providing irradiation in the substrate,
a radiation detection unit for detecting particles in the fluid in the substrate,
at least one of the radiation source and the radiation detection unit being configured so as to obtain detection in one or more distinct detection sheets in the substrate,
wherein the system further comprises an actuator configured for imparting an oscillating mechanical movement of the substrate holder with respect to the radiation detection unit and the radiation source, the oscillating mechanical movement comprising a movement component in a direction perpendicular to a plane wherein the one or more detection sheets are extending,
wherein the actuator is configured for imparting an oscillation of the substrate holder at a frequency in a range of tens of Hz to 100kHz.