US 11,933,701 B2
Devices and methods for sample analysis with serial dilution
Wendian Shi, Irvine, CA (US); Yuan Gao, Irvine, CA (US); and Yuzhe Ding, Irvine, CA (US)
Assigned to CytoChip Inc., Irvine, CA (US)
Filed by CytoChip, Inc., Irvine, CA (US)
Filed on Apr. 29, 2023, as Appl. No. 18/309,800.
Application 18/309,800 is a continuation of application No. 16/971,623, granted, now 11,674,869, previously published as PCT/US2019/019555, filed on Feb. 26, 2019.
Claims priority of provisional application 62/635,996, filed on Feb. 27, 2018.
Prior Publication US 2023/0266205 A1, Aug. 24, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 1/20 (2006.01); G01N 1/38 (2006.01)
CPC G01N 1/2035 (2013.01) [G01N 1/38 (2013.01); G01N 2001/2057 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A device comprising a fluidic cartridge, wherein the fluidic cartridge comprises:
a first chamber to receive a sample mixture 1;
a metering chamber for metering a first portion of the sample mixture 1, the metering chamber being connected to the first chamber; and
a reader instrument for receiving the device and performing a sample analysis,
wherein:
a driving mechanism is applied to the fluidic cartridge to meter the first portion of the sample mixture 1 in the metering chamber;
the driving mechanism is configured to drive the sample mixture 1 to contact a hydrophilic surface outside the first chamber, the hydrophilic surface being a part of a surface of the metering chamber; and
the driving mechanism is configured to be stopped after the sample mixture 1 contacting the hydrophilic surface.