	US 11,932,864 B2
	Immunomodulating transgenic plants and related methods
R. Michael Raab, Arlington, MA (US); Oleg Bougri, Winchester, MA (US); Matthew Parker, Cambridge, MA (US); and Philip A. Lessard, Framingham, MA (US)
Assigned to AGRIVIDA INC., Woburn, MA (US)
Filed by AGRIVIDA, INC., Woburn, MA (US)
Filed on May 19, 2022, as Appl. No. 17/748,507.
Application 17/748,507 is a continuation of application No. 16/609,633, granted, now 11,390,879, previously published as PCT/US2018/034856, filed on May 29, 2018.
Claims priority of provisional application 62/512,444, filed on May 30, 2017.
Prior Publication US 2022/0282269 A1, Sep. 8, 2022
Int. Cl. C12N 15/82 (2006.01); A61P 33/00 (2006.01); C07K 14/54 (2006.01); C07K 16/24 (2006.01); A61K 39/00 (2006.01)

CPC C12N 15/8258 (2013.01) [A61P 33/00 (2018.01); C07K 14/5428 (2013.01); C07K 16/244 (2013.01); A61K 2039/505 (2013.01); A61K 2039/542 (2013.01); C07K 2317/13 (2013.01); C07K 2317/22 (2013.01); C07K 2317/23 (2013.01); C07K 2317/569 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01)]

19 Claims

1. A transgenic plant or tissues thereof comprising a synthetic polynucleotide encoding an anti-IL-10 single domain antibody, wherein the anti-IL-10 single domain antibody comprises an amino acid sequence of SEQ ID NO: 146, and binds a polypeptide comprising an amino acid sequence of SEQ ID NO: 80 with an EC₅₀of 60 nM or less, as measured by ELISA.