US 11,932,839 B2
Microengineered tissue barrier system
YongTae Kim, Atlanta, GA (US); Song lh Ahn, Atlanta, GA (US); Taeyoung Kim, Atlanta, GA (US); and Jeongkee Yoon, Atlanta, GA (US)
Assigned to GEORGIA TECH RESEARCH CORPORATION, Atlanta, GA (US)
Filed by Georgia Tech Research Corporation, Atlanta, GA (US)
Filed on Dec. 7, 2020, as Appl. No. 17/114,282.
Claims priority of provisional application 62/945,501, filed on Dec. 9, 2019.
Prior Publication US 2021/0171889 A1, Jun. 10, 2021
Int. Cl. C12M 1/12 (2006.01); C12M 3/00 (2006.01); C12M 3/06 (2006.01); G01N 33/50 (2006.01)
CPC C12M 23/16 (2013.01) [C12M 23/42 (2013.01); C12M 25/02 (2013.01); G01N 33/502 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A microfluidic device comprising:
an insert comprising a first central channel;
a base comprising a second central channel, a third side channel, a fourth side channel, a fifth passage channel connecting the second central channel and the third side channel, and a sixth passage channel connecting the second central channel and the fourth side channel; and
a porous membrane positioned between the insert and the base,
wherein the third side channel and the fourth side channel have a lower channel height than the second central channel, wherein the base further comprises a first fluid reservoir and a second fluid reservoir, and wherein the base comprises a seventh passage channel connecting the third side channel and the first fluid reservoir, and an eighth passage channel connecting the fourth side channel and the second fluid reservoir.