CPC C07K 16/2896 (2013.01) [A61K 35/17 (2013.01); A61K 38/1774 (2013.01); A61K 39/00 (2013.01); A61K 39/39558 (2013.01); C07K 14/4748 (2013.01); C07K 14/705 (2013.01); C07K 14/7051 (2013.01); C12N 5/0636 (2013.01); A61K 2039/505 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/585 (2013.01); C07K 2319/33 (2013.01); C12N 7/00 (2013.01); C12N 2501/515 (2013.01)] | 9 Claims |
1. A method of stimulating a T cell-mediated immune response and treating colorectal cancer in a human patient, the method comprising:
contacting a population of cells comprising guanylate cyclase 2C (GUCY2C) comprising the amino acid sequence of SEQ ID NO: 33, in a human patient with a population of modified T cells comprising a chimeric antigen receptor (CAR),
and stimulating a T cell-mediated immune response and treating colorectal cancer in a human patient,
wherein the CAR comprises an extracellular domain, a transmembrane domain, and an intracellular domain, the extracellular domain comprising the amino acid sequences SEQ ID NO: 14.
|