US 11,932,698 B2
Anti-mesothelin chimeric antigen receptor (CAR) constructs and uses thereof
Qing Dai, Nanjing (CN); Jian Liu, Nanjing (CN); Shuai Yang, Nanjing (CN); Kun Jiang, Nanjing (CN); Yuanyuan Peng, Nanjing (CN); Chen Hu, Nanjing (CN); and Shu Wu, Nanjing (CN)
Assigned to Nanjing Legend Biotech Co., Ltd., Nanjing (CN)
Appl. No. 17/270,970
Filed by Nanjing Legend Biotech Co. Ltd., Jiangsu (CN)
PCT Filed Aug. 29, 2019, PCT No. PCT/CN2019/103215
§ 371(c)(1), (2) Date Feb. 24, 2021,
PCT Pub. No. WO2020/043152, PCT Pub. Date Mar. 5, 2020.
Claims priority of application No. PCT/CN2018/103050 (WO), filed on Aug. 29, 2018; and application No. PCT/CN2019/083918 (WO), filed on Apr. 23, 2019.
Prior Publication US 2021/0269537 A1, Sep. 2, 2021
Int. Cl. C07K 16/28 (2006.01); A61K 35/17 (2015.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01); A61P 35/00 (2006.01); C07K 14/705 (2006.01); C07K 14/71 (2006.01); C07K 14/725 (2006.01); C07K 16/30 (2006.01)
CPC C07K 16/2869 (2013.01) [A61K 35/17 (2013.01); A61P 35/00 (2018.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70521 (2013.01); C07K 14/70578 (2013.01); C07K 14/71 (2013.01); C07K 16/3076 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5158 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/569 (2013.01); C07K 2317/622 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/30 (2013.01); C07K 2319/33 (2013.01)] 24 Claims
 
1. An antibody or antigen binding fragment that specifically binds mesothelin, comprising:
a single domain antibody (sdAb) comprising a complementarity determining region 1 (CDR1), a CDR2 and a CDR3 having the polypeptide sequences of:
a. SEQ ID NOs:66, 134, and 202, respectively;
b. SEQ ID NOs:67, 135, and 203, respectively; or
c. SEQ ID NOs:34, 102, and 170, respectively.