	US 11,932,686 B2
	Use of regulatory T cell-specific surface protein LRIG-1
Sang-kyou Lee, Seoul (KR)
Assigned to Good T Cells, Inc., Seoul (KR)
Filed by GOOD T CELLS, INC., Seoul (KR)
Filed on Jul. 13, 2021, as Appl. No. 17/374,224.
Application 17/374,224 is a continuation of application No. 16/233,738, filed on Dec. 27, 2018, granted, now 11,091,538.
Application 16/233,738 is a continuation of application No. 14/427,421, previously published as PCT/KR2012/000532, filed on Jan. 20, 2012.
Claims priority of application No. 10-2011-0007022 (KR), filed on Jan. 24, 2011.
Prior Publication US 2021/0340235 A1, Nov. 4, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/18 (2006.01); A61K 35/17 (2015.01); A61K 38/00 (2006.01); C07K 14/47 (2006.01); C12N 15/113 (2010.01); C12Q 1/6876 (2018.01); G01N 33/50 (2006.01); G01N 33/68 (2006.01); G01N 33/94 (2006.01)

CPC C07K 16/18 (2013.01) [A61K 35/17 (2013.01); C07K 14/47 (2013.01); C12N 15/113 (2013.01); C12N 15/1138 (2013.01); C12Q 1/6876 (2013.01); G01N 33/5023 (2013.01); G01N 33/505 (2013.01); G01N 33/6854 (2013.01); G01N 33/6872 (2013.01); G01N 33/9493 (2013.01); A61K 38/00 (2013.01); C12N 2310/11 (2013.01); C12N 2310/14 (2013.01); C12N 2310/17 (2013.01); C12Q 2600/136 (2013.01); C12Q 2600/158 (2013.01)]

5 Claims

1. A method for screening an agent for Lrig (leucine-rich repeats and immunoglobulin-like domain) up-regulating activity comprising:

(a) contacting the agent with a regulatory T cell expressing Lrig protein;

(b) measuring an expression level of the Lrig expressed by the regulatory T cell; and

(c) determining that the agent has Lrig up-regulating activity when the expression level of Lrig of the regulatory T cell is up-regulated.