US 11,932,656 B1
Thieno[2,3-d]pyrimidines as COX-2 inhibitors
Katharigatta N. Venugopala, Al-Ahsa (SA); Pran Kishore Deb, Ranchi (IN); Raghu Prasad Mailavaram, Maharashtra (IN); Nizar A. Al-Shar'i, Ar-Ramtha (JO); Swastika Ganguly, Ranchi (IN); Bapi Gorain, Ranchi (IN); Lim Tse Mun, Kuala Lumpur (MY); and Jamie Kow Kean Hing, Kuala Lumpur (MY)
Assigned to KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed by KING FAISAL UNIVERSITY, Al-Ahsa (SA)
Filed on Oct. 6, 2023, as Appl. No. 18/377,459.
Int. Cl. C07D 495/04 (2006.01); A61P 29/00 (2006.01)
CPC C07D 495/04 (2013.01) [A61P 29/00 (2018.01)] 16 Claims
 
1. A method of inhibiting cyclooxygenase-2 (COX-2) in a patient comprising administering to a patient in need thereof a compound having the formula I:

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt, ester, stereoisomer, or solvate thereof, wherein:
R1 is selected from the group consisting of —CH2-phenyl and —NH-(C═O)-phenyl,
wherein the phenyl in either of the —CH2-phenyl and —NH-(C═O)-phenyl is substituted with one substituent selected from the group consisting of a halogen, methoxy, and CF3.