US 11,932,631 B2
Process for preparing aficamten
Denise Andersen, Montara, CA (US); Matthew Pfeiffer, Salt Lake City, UT (US); Norma Tom, Belmont, CA (US); and Bradley P. Morgan, South San Francisco, CA (US)
Assigned to CYTOKINETICS, INC., South San Francisco, CA (US)
Filed by Cytokinetics, Inc., South San Francisco, CA (US)
Filed on Aug. 2, 2022, as Appl. No. 17/816,898.
Claims priority of provisional application 63/203,888, filed on Aug. 3, 2021.
Prior Publication US 2023/0045450 A1, Feb. 9, 2023
Int. Cl. C07D 413/12 (2006.01); C07C 255/58 (2006.01)
CPC C07D 413/12 (2013.01) 32 Claims
 
1. A method of preparing a compound of Formula (1):

OG Complex Work Unit Chemistry
or a salt thereof, comprising:
(i) converting a compound of Formula (7)

OG Complex Work Unit Chemistry
to a compound of Formula (6)

OG Complex Work Unit Chemistry
(ii) converting the compound of Formula (6) to a compound of Formula (5)

OG Complex Work Unit Chemistry
and
(iii) converting the compound of Formula (5) to the compound of Formula (1) or salt thereof.