US 11,932,600 B2
Biaryl derivative
Takashi Tsuji, Tokyo (JP); Yasunobu Kurosaki, Tokyo (JP); Koutaro Ishibashi, Tokyo (JP); and Anthony B. Pinkerton, La Jolla, CA (US)
Assigned to Daiichi Sankyo Company Limited, Tokyo (JP); and Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA (US)
Appl. No. 17/287,445
Filed by DAIICHI SANKYO COMPANY, LIMITED, Tokyo (JP); and SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, La Jolla, CA (US)
PCT Filed Oct. 22, 2019, PCT No. PCT/US2019/057314
§ 371(c)(1), (2) Date Apr. 21, 2021,
PCT Pub. No. WO2020/086504, PCT Pub. Date Apr. 30, 2020.
Claims priority of provisional application 62/749,590, filed on Oct. 23, 2018.
Prior Publication US 2021/0355087 A1, Nov. 18, 2021
Int. Cl. C07D 213/71 (2006.01); A61P 3/14 (2006.01); C07D 239/38 (2006.01); C07D 401/12 (2006.01)
CPC C07D 213/71 (2013.01) [A61P 3/14 (2018.01); C07D 239/38 (2013.01); C07D 401/12 (2013.01)] 16 Claims
 
1. A compound represented by formula (I):

OG Complex Work Unit Chemistry
wherein
X1 represents a nitrogen atom or CR9,
R1 represents a hydrogen atom, a C1-C6 alkyl group or a C1-C6 alkoxy group,
R2 represents a halogen atom,
R3 represents a hydrogen atom or a halogen atom,
R4 represents a hydrogen atom or a halogen atom,
R5 represents a C1-C3 alkylsulfonyl group, a C1-C6 alkyl group (wherein the alkyl group is substituted by one group selected from a C1-C3 alkylsulfonyl group, a carboxy group and a tetrazolyl group), a C1-C6 haloalkyl group (wherein the haloalkyl group is substituted by one group selected from a C1-C3 alkylsulfonyl group, a carboxy group and a tetrazolyl group), a C1-C6 alkoxy group (wherein the alkoxy group is substituted by one group selected from a C1-C3 alkylsulfonyl group, a carboxy group and a tetrazolyl group) or a C1-C6 alkylamino group (wherein the alkylamino group is substituted by one group selected from a C1-C3 alkylsulfonyl group, a carboxy group and a tetrazolyl group), and
R9 represents a hydrogen atom, a halogen atom, a C1-C3 alkylsulfonyl group, a C1-C6 alkyl group or a C1-C6 alkoxy group,
or a pharmacologically acceptable salt thereof.