US 11,931,742 B2
Carrying module, nucleic acid loading device and use thereof
Songzhen Zhang, Shenzhen (CN); Zefei Jiang, Shenzhen (CN); Guangming Wang, Shenzhen (CN); Ping Wu, Shenzhen (CN); Zhiliang Zhou, Shenzhen (CN); and Qin Yan, Shenzhen (CN)
Assigned to GENEMIND BIOSCIENCES COMPANY LIMITED, (CN)
Appl. No. 16/960,748
Filed by GENEMIND BIOSCIENCES COMPANY LIMITED, Shenzhen (CN)
PCT Filed Dec. 12, 2018, PCT No. PCT/CN2018/120525
§ 371(c)(1), (2) Date Jul. 8, 2020,
PCT Pub. No. WO2019/144717, PCT Pub. Date Aug. 1, 2019.
Claims priority of application No. 201810063798.2 (CN), filed on Jan. 23, 2018.
Prior Publication US 2020/0338564 A1, Oct. 29, 2020
Int. Cl. B01L 7/00 (2006.01); B01L 3/00 (2006.01); B01L 9/00 (2006.01); C12Q 1/6806 (2018.01)
CPC B01L 7/525 (2013.01) [B01L 3/502715 (2013.01); B01L 3/50273 (2013.01); B01L 7/52 (2013.01); B01L 9/523 (2013.01); C12Q 1/6806 (2013.01); B01L 2200/147 (2013.01); B01L 2200/148 (2013.01); B01L 2200/16 (2013.01); B01L 2300/041 (2013.01); B01L 2300/06 (2013.01); B01L 2300/0627 (2013.01); B01L 2300/1805 (2013.01); B01L 2300/185 (2013.01); B01L 2300/1894 (2013.01); B01L 2400/0487 (2013.01); B01L 2400/049 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A nucleic acid loading device, comprising:
a housing;
a carrying module in the housing comprising an accommodating seat and a temperature control unit, and a reactor detachably connected to the accommodating seat, wherein the reactor is a chip for receiving a nucleic acid molecule sample, the nucleic acid loading being performed in the reactor, the temperature control unit comprising a semiconductor cooler, a heat conducting body and a temperature sensor, the semiconductor cooler comprising a first face and a second face opposite to each other, the heat conducting body being connected to the first face and the accommodating seat, the temperature sensor being arranged in the heat conducting body, and the temperature sensor being configured to detect a temperature of the heat conducting body;
a motion module in the housing comprising a partition plate, a support platform, a first driving mechanism, a carrying member configured to carry a reagent container including a reagent, and a second driving mechanism, the support platform being detachably and movably arranged on the partition plate, the first driving mechanism being fixed on the partition plate and configured to drive the support platform to move along a first direction relative to the partition plate, the second driving mechanism being fixed on the support platform and configured to drive the carrying member to move along a second direction relative to the support platform, the second direction being perpendicular to the first direction;
a liquid circuit module in the housing configured to control the reagent to flow into and out of the reactor, and comprising a pump configured to provide negative pressure; and
a control module in the housing connected with the carrying module, the motion module and the liquid circuit module, and configured to control operation of the first driving mechanism, the second driving mechanism, the liquid circuit module and the temperature control unit,
wherein the partition plate separates the housing into first and second compartments with at least the pump and the control module in the first compartment and at least the carrying module, the support platform, the first driving mechanism, and the second driving mechanism in the second compartment.