CPC B01J 20/265 (2013.01) [B01D 15/327 (2013.01); B01D 15/362 (2013.01); B01D 15/363 (2013.01); B01J 20/285 (2013.01); B01J 20/3274 (2013.01); B01J 39/05 (2017.01); B01J 39/07 (2017.01); B01J 41/05 (2017.01); B01J 41/07 (2017.01); B01J 2219/00844 (2013.01); B01J 2219/00846 (2013.01)] | 42 Claims |
1. A functionalised chromatography medium, comprising:
i) at least one non-woven layer of polymeric nanofibres comprising a plurality of nanofibre-nanofibre fusion points;
ii) a grafted polymer coating covering said polymeric nanofibres and said nanofibre-nanofibre fusion points, wherein the grafted polymer coating comprises polymer molecules which are single-point covalently tethered to said polymeric nanofibres, and wherein the polymer molecules comprise glycidol monomer residues formed from a plurality of compounds of formula
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iii) a plurality of ligand groups covalently bound to said grafted polymer coating, wherein said ligand groups are capable of interacting with a target biomolecule.
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