US 11,931,569 B2
Method for changing blood brain barrier permeability
Yael Mardor, Netanya (IL); Shirley Sharabi, Ganei Tikva (IL); Itzik Cooper, Rehovot (IL); David Last, Jerusalem (IL); David Guez, Tel Aviv (IL); Dianne Daniels Elmakias, Ramat Hasharon (IL); and Yael Bresler, Tel Aviv (IL)
Assigned to TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE & SERVICES LTD., Ramat Gan (IL)
Appl. No. 16/980,104
Filed by TEL HASHOMER MEDICAL RESEARCH, INFRASTRUCTURE AND SERVICES LTD., Ramat Gan (IL)
PCT Filed Mar. 12, 2019, PCT No. PCT/IL2019/050276
§ 371(c)(1), (2) Date Sep. 11, 2020,
PCT Pub. No. WO2019/175871, PCT Pub. Date Sep. 19, 2019.
Claims priority of provisional application 62/641,522, filed on Mar. 12, 2018.
Prior Publication US 2021/0016084 A1, Jan. 21, 2021
Int. Cl. A61N 1/32 (2006.01); A61N 1/02 (2006.01); A61N 2/00 (2006.01); A61N 2/02 (2006.01)
CPC A61N 1/327 (2013.01) [A61N 1/025 (2013.01); A61N 2/002 (2013.01); A61N 2/02 (2013.01)] 10 Claims
OG exemplary drawing
 
1. A method for treating a subject in need thereof, the method comprising:
selecting a treatment region within a central nervous system (CNS);
mounting, on an external surface of the subject, an electric field source that comprises one or both of (i) a plurality of electrodes and (ii) a magnetic field source configured to generate a changing magnetic field; and
applying a pulsed electric field with said electric field source to at least a portion of the CNS,
wherein the pulsed electric field has an electric field strength of less than 148 V/cm and a frequency of less than 75 Hz within the treatment region, being below a threshold for inducing electroporation in the treatment region,
wherein applying the pulsed electric field induces disruptive permeability of a blood brain barrier or a blood cerebrospinal fluid barrier in the treatment region.