CPC A61L 27/52 (2013.01) [A61K 9/0019 (2013.01); A61K 9/1635 (2013.01); A61K 9/1641 (2013.01); A61K 9/1652 (2013.01); A61K 39/39 (2013.01); A61L 27/54 (2013.01); A61L 27/56 (2013.01); C08H 1/00 (2013.01); A61K 2039/60 (2013.01); A61K 2039/6093 (2013.01); A61L 2300/426 (2013.01); A61L 2300/64 (2013.01); A61L 2400/06 (2013.01)] | 9 Claims |
1. A method of delivering a microgel system to a subject, the method comprising:
(a) delivering to the subject a plurality of microgel particles, wherein at least one microgel particle of the microgel particles comprises
(i) a core comprising one or more hydrogel polymer components; and
(ii) one or more annealing components in a presence of an annealing agent, wherein the one or more annealing components comprises a vinyl unsaturated double bond, a K-peptide, a Q-peptide, or any combination thereof; and
(b) exposing the plurality of microgel particles to the annealing agent, thereby coupling adjacent microgel particles of the plurality of microgel particles together, to form a covalently-stabilized scaffold of microgel particles comprising pores between the adjacent microgel particles, wherein the pores are on the 10 micrometer scale and are substantially devoid of the hydrogel polymer.
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