	US 11,931,459 B2
	Treatment of pain in pediatric patients by administration of sustained-release liposomal anesthetic compositions
Roy Winston, Parsippany, NJ (US)
Assigned to Pacira Pharmaceuticals, Inc., Parsippany, NJ (US)
Filed by Pacira Pharmaceuticals, Inc., Parsippany, NJ (US)
Filed on Mar. 17, 2022, as Appl. No. 17/697,261.
Claims priority of provisional application 63/163,672, filed on Mar. 19, 2021.
Prior Publication US 2022/0387318 A1, Dec. 8, 2022
Int. Cl. A61K 9/127 (2006.01); A61K 9/107 (2006.01); A61K 31/4375 (2006.01); A61K 31/66 (2006.01)

CPC A61K 9/1271 (2013.01) [A61K 9/107 (2013.01); A61K 31/4375 (2013.01); A61K 31/66 (2013.01)]

22 Claims

1. A method of treating pain in a pediatric subject aged 12 to <17 years undergoing spine surgery, the method comprising:

administering to the subject about 4 milligrams of a pharmaceutical composition per kilogram of the subject's body weight, the pharmaceutical composition comprising:

a) a multivesicular liposome comprising: at least one amphipathic lipid, and at least one neutral lipid; and

b) an aqueous phase comprising bupivacaine phosphate,

wherein the aqueous phase is encapsulated within the multivesicular liposome.