US 11,931,378 B2
Method and process to make chitosan-doped strontium oxide nanocomposite for bactericidal applications
Souraya Goumri-Said, Riyadh (SA); Mohammed Benali Kanoun, Riyadh (SA); Salamat Ali, Lahore (PK); Junaid Haider, Tianjin (CN); Ali Haider, Lahore (PK); and Muhammad Ikram, Lahore (PK)
Assigned to Alfaisal University, Riyadh (SA)
Filed by Alfaisal University, Riyadh (SA)
Filed on Dec. 15, 2021, as Appl. No. 17/551,882.
Prior Publication US 2023/0190788 A1, Jun. 22, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 33/14 (2006.01); A61K 9/08 (2006.01); A61K 47/02 (2006.01); A61K 47/36 (2006.01); A61P 31/04 (2006.01); C01F 11/24 (2006.01); C08L 5/08 (2006.01)
CPC A61K 33/14 (2013.01) [A61K 9/08 (2013.01); A61K 47/02 (2013.01); A61K 47/36 (2013.01); A61P 31/04 (2018.01); C01F 11/24 (2013.01); C08L 5/08 (2013.01)] 14 Claims
 
1. A method, comprising;
dissolving a strontium chloride hexahydrate in water and stirring the solution for 2 hours to make a dissolved solution of the strontium chloride hexahydrate;
adjusting a pH of the dissolved solution of strontium chloride hexahydrate to a specific pH by adding sodium hydroxide solution for 2 hours to form a precipitate of a strontium chloride hexahydrate nanoparticle in solution;
centrifuging a strontium chloride hexahydrate nanoparticle in solution to collect a pellet of the precipitate of the strontium chloride hexahydrate nanoparticle;
heating the pellet of the strontium chloride hexahydrate nanoparticle at 120° C. for 24 hours and grinding the heated pellet to obtain a powder of strontium chloride hexahydrate nanoparticles;
preparing a strontium chloride hexahydrate nanoparticle solution using the powder of strontium chloride hexahydrate nanoparticles in distilled water with various concentrations of a chitosan the specific pH using a specific basic solution to create a chitosan (CS)-doped Strontium oxide (SrO) nanocomposite; and
inhibiting a bacterial growth by adding the CS-doped SrO nanocomposite in a cell infected with a bacteria.