US 11,931,331 B2
Compositions and methods for treating the eye
Wen-Hwa Ting Li, Cranbury, NJ (US); Khalid Mahmood, Lawrenceville, NJ (US); Ramine Parsa, Lawrenceville, NJ (US); Mingqi Bai, Jacksonville, FL (US); and Kenneth T. Holeva, Ponte Vedra Beach, FL (US)
Assigned to Johnson & Johnson Surgical Vision, Inc., Irvine, CA (US)
Filed by Johnson & Johnson Surgical Vision, Inc., Santa Ana, CA (US)
Filed on Dec. 1, 2021, as Appl. No. 17/539,776.
Application 17/539,776 is a division of application No. 16/519,145, filed on Jul. 23, 2019, granted, now 11,197,841.
Claims priority of provisional application 62/703,939, filed on Jul. 27, 2018.
Prior Publication US 2022/0087965 A1, Mar. 24, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/202 (2006.01); A61K 31/192 (2006.01); A61K 35/74 (2015.01); A61K 36/54 (2006.01); A61K 36/75 (2006.01); A61K 47/36 (2006.01); A61K 47/38 (2006.01); A61P 27/04 (2006.01)
CPC A61K 31/202 (2013.01) [A61K 31/192 (2013.01); A61K 35/74 (2013.01); A61K 36/54 (2013.01); A61K 36/75 (2013.01); A61K 47/36 (2013.01); A61K 47/38 (2013.01); A61P 27/04 (2018.01)] 19 Claims
 
1. A method for treating the symptoms associated with dry eye comprising the step of administering a composition comprising:
i) a safe and effective amount of a compound and/or extract having retinol-like properties and/or benefits for use in treating dry eye selected from one or more of: botanical extracts from plants of the genus Acronychia, Licaria, Calendula and/or Trigonella; bacterial extracts of the genus Actinomyces; and compounds of Formula (I):

OG Complex Work Unit Chemistry
wherein—
the dotted lines represent simple or double bound;
R1 represent an H, a carbonated chain, linear, cyclic, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms;
R2 represent a carbonated chain, linear, cyclic ringed, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms; preferably a methyl (—CH3) or methylene (═CH2) moiety;
a represent a carbonated chain, linear, ringed, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms; and
ii) optionally, an ophthalmologically acceptable carrier.