US 11,931,163 B2
Method and apparatus to determine the malignant potential of pancreatic cysts using light scattering spectroscopy
Lev T. Perelman, Brookline, MA (US)
Assigned to Beth Israel Deaconess Medical Center, Inc., Boston, MA (US)
Appl. No. 16/487,768
Filed by Beth Israel Deaconess Medical Center, Inc., Boston, MA (US)
PCT Filed Feb. 23, 2018, PCT No. PCT/US2018/019563
§ 371(c)(1), (2) Date Aug. 21, 2019,
PCT Pub. No. WO2018/156984, PCT Pub. Date Aug. 30, 2018.
Claims priority of provisional application 62/469,982, filed on Mar. 10, 2017.
Claims priority of provisional application 62/462,510, filed on Feb. 23, 2017.
Prior Publication US 2020/0297266 A1, Sep. 24, 2020
Int. Cl. A61B 5/00 (2006.01); A61B 8/08 (2006.01); A61B 10/00 (2006.01)
CPC A61B 5/425 (2013.01) [A61B 5/0075 (2013.01); A61B 5/0084 (2013.01); A61B 8/0841 (2013.01); A61B 10/0045 (2013.01); A61B 2010/0061 (2013.01); A61B 2562/0242 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A spatial gating probe for performing light scattering spectroscopy on tissue, the spatial gating probe comprising:
a housing;
a plurality of fiber-optic cables disposed within the housing, wherein:
the plurality of fiber-optic cables comprises at least one source fiber and at least one detector fiber;
the at least one source fiber is configured to emit light onto the tissue;
the at least one detector fiber is configured to receive light reflected from the tissue;
the plurality of fiber-optic cables being constructed and arranged in a hexagonal shape such that the at least one source fiber is disposed at an outer edge of the hexagonal shape;
the at least one detector fiber comprises at least one first detector fiber and at least one second detector fiber;
the at least one first detector fiber is disposed at a distance d1 from the at least one source fiber;
the at least one second detector fiber is disposed at a distance d2 from the at least one source fiber; and
d2 is greater than d1; and
first and second spectrometers,
wherein the at least one first detector fiber is configured to obtain a first spectrum, and the at least one second detector fiber is configured to obtain a second spectrum,
wherein the first and second spectrometers are configured to analyze, respectively, the first spectrum and the second spectrum to subtract the second spectrum obtained by the at least one second detector fiber from the first spectrum obtained by the at least one first detector fiber,
wherein the first spectrum and second spectrum are unpolarized signals.