US 12,255,059 B2
Method and device for multiple transition monitoring
Stefan Quint, Munich (DE); Florian Schweinberger, Munich (DE); and Benjamin Tiemann, Munich (DE)
Assigned to Roche Diagnostics Operations, Inc., Indianapolis, IN (US)
Filed by Roche Diagnostics Operations, Inc., Indianapolis, IN (US)
Filed on Jun. 6, 2022, as Appl. No. 17/805,482.
Application 17/805,482 is a continuation of application No. PCT/EP2020/086399, filed on Dec. 16, 2020.
Claims priority of application No. 19216963 (EP), filed on Dec. 17, 2019.
Prior Publication US 2022/0319827 A1, Oct. 6, 2022
Int. Cl. H01J 49/42 (2006.01)
CPC H01J 49/4215 (2013.01) [H01J 49/429 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A method for multiple transition monitoring of at least one analyte in a sample using a quadrupole mass analyzer, the method comprising the following steps:
a) at least one voltage application step, wherein in the voltage application step a direct current (DC) voltage and a radio frequency (AC) voltage are applied between two pairs of electrodes of at least one mass filter of the quadrupole mass analyzer, wherein the AC voltage has an amplitude VAC and the DC voltage has an applicable voltage VDC, wherein a supplementary AC voltage is superimposed on top of the AC and the DC voltage, wherein an amplitude ΔVDC of the supplementary AC voltage is

OG Complex Work Unit Math
wherein VDC,max is a maximum voltage output of the DC voltage and b is a bit size of at least one electronics board of the mass filter of the quadrupole mass analyzer, wherein the electronics board is configured for providing the AC and DC voltages to the electrodes of the mass filter, wherein the electronics board comprises at least one digital-to-analog converter;
b) at least one measurement step, wherein at least one transition of the analyte is determined with at least one detector of the quadrupole mass analyzer.