US 12,253,461 B2
Open-loop/closed-loop process control on the basis of a spectroscopic determination of undetermined substance concentrations
Marek Höhse, Göttingen (DE); Alexander Graf, Ulm (DE); and Christian Grimm, Heiligenstadt (DE)
Assigned to Sartorius Stedim Biotech GMBH, Gottingen (DE)
Appl. No. 17/800,445
Filed by Sartorius Stedim Biotech GmbH, Göttingen (DE)
PCT Filed Feb. 18, 2021, PCT No. PCT/EP2021/053990
§ 371(c)(1), (2) Date Aug. 17, 2022,
PCT Pub. No. WO2021/204450, PCT Pub. Date Oct. 14, 2021.
Claims priority of application No. 102020002256.1 (DE), filed on Apr. 9, 2020.
Prior Publication US 2023/0102813 A1, Mar. 30, 2023
Int. Cl. G01N 21/33 (2006.01); G01N 21/85 (2006.01)
CPC G01N 21/33 (2013.01) [G01N 21/85 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A method for open-loop or closed-loop control of a process based on a projection of an unknown concentration of one or several substances in a test sample using spectroscopy the method comprising the steps:
detecting reference spectrums from a plurality of concentration samples, wherein each concentration sample contains a known concentration of the one or several substances, and wherein at least two of the concentration samples have different known concentrations from each other;
generating a plurality of quantitative models on the basis of the reference spectrums of the concentration samples, wherein each quantitative model maps to at least one spectral measurand of the reference spectrums to concentrations in a respective concentration range, wherein the concentration ranges for at least two of the quantitative models are not identical;
detecting a sample spectrum from the test sample containing the unknown concentration;
mapping the sample spectrum to at least one quantitative model from the plurality of quantitative models;
applying the at least one mapped quantitative model to the sample spectrum to determine a projected value for the undetermined concentration;
operating the process by open-loop and/or closed-loop control for at least one parameter based on the projected value for the undetermined concentration; and
wherein a higher weight factor for application on the sample spectrum is assigned to at least one partial range that exhibits a linear dependency between wavelengths and measurands, wherein the weight factor is applied manually or by an algorithm.