| CPC F16K 99/0015 (2013.01) [F16K 99/0028 (2013.01); F16K 99/0059 (2013.01); H01L 21/67017 (2013.01)] | 20 Claims |

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1. An apparatus comprising:
a substrate having one or more microfluidic valve structures, each microfluidic valve structure of the one or more microfluidic valve structures including:
a diaphragm having a first side, and a second side opposite the first side;
a base;
an orifice in the base; and
a raised seat structure, wherein, for each microfluidic valve structure:
the diaphragm is made from a non-elastomeric material,
the raised seat structure extends from the base towards the first side of the diaphragm,
a surface of the raised seat structure facing the diaphragm is separated from the first side of the diaphragm by a gap when the microfluidic valve structure is in an undeformed state, and
the diaphragm, the raised seat structure, and the gap of that microfluidic valve structure are sized such that, when that microfluidic valve structure is transitioned to an actuated state by pressurizing the second side of the diaphragm to a first pressure,
a portion of the diaphragm is caused to elastically deform towards, and seal against, the raised seat structure.
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