Assigned to UNIVERSITY OF CENTRAL OKLAHOMA, Edmond, OK (US)
Filed by University of Central Oklahoma, Edmond, OK (US)
Filed on Feb. 15, 2024, as Appl. No. 18/442,805.
Application 18/442,805 is a continuation of application No. 17/553,539, filed on Dec. 16, 2021, granted, now 11,913,139.
Application 17/553,539 is a continuation of application No. 17/229,612, filed on Apr. 13, 2021, granted, now 11,208,735, issued on Dec. 28, 2021.
Application 17/229,612 is a continuation in part of application No. 16/909,077, filed on Jun. 23, 2020, granted, now 10,995,425, issued on May 4, 2021.
Application 16/909,077 is a continuation in part of application No. 16/833,116, filed on Mar. 27, 2020, granted, now 10,876,223, issued on Dec. 29, 2020.
Application 16/833,116 is a continuation of application No. 16/460,589, filed on Jul. 2, 2019, granted, now 10,640,888, issued on May 5, 2020.
Prior Publication US 2024/0200230 A1, Jun. 20, 2024
1. A fiber membrane, comprising electrospun fiberizeable material in at least three adjacent layers of nanofibers, each layer comprising a plurality of aligned nanofibers oriented at oblique angles relative to nanofibers in adjacent layers, said plurality of aligned nanofibers in each layer extending from a first membrane edge to a second membrane edge, wherein a plurality of aligned nanofibers in each layer cross a plurality of aligned nanofibers in adjacent layers at a plurality of distinct points of intersection, forming a crossing at each distinct point of intersection consisting of three crossing nanofibers extending directionally as six radials from each of said distinct points of intersection, wherein relative cross-alignment angles between said six radials at each distinct point of intersection are in the range of 50 to 70 degrees, and wherein said relative cross-alignment angles of said aligned nanofibers and spacing between said aligned nanofibers each have a specific average numerical value in said membrane and comprise a structure having porosity required for cell migration and exudate flow from a wound, and wherein said aligned nanofibers comprise a polymer and any one or combination of a chromogenic agent, an antimicrobial agent, a hemostatic agent, an analgesic agent, a regenerative agent, an immune modulator, an oxygenating agent, and a pH stabilizer.
