US 12,252,748 B2
Kit, device and method for detecting prostate cancer
Makiko Yoshimoto, Kamakura (JP); Hiroko Sudo, Kamakura (JP); Atsuko Miyano, Kamakura (JP); Satoko Kozono, Kamakura (JP); Takahiro Ochiya, Tokyo (JP); Hiroyuki Fujimoto, Tokyo (JP); Fumihiko Urabe, Tokyo (JP); and Juntaro Matsuzaki, Tokyo (JP)
Assigned to TORAY INDUSTRIES, INC., Tokyo (JP); and NATIONAL CANCER CENTER, Tokyo (JP)
Filed by TORAY INDUSTRIES, INC., Tokyo (JP); and NATIONAL CANCER CENTER, Tokyo (JP)
Filed on Jan. 9, 2024, as Appl. No. 18/408,056.
Application 18/408,056 is a division of application No. 17/988,959, filed on Nov. 17, 2022, granted, now 11,905,565.
Application 17/988,959 is a division of application No. 17/265,060, granted, now 11,535,899, issued on Dec. 27, 2022, previously published as PCT/JP2019/031550, filed on Aug. 9, 2019.
Claims priority of application No. 2018-151952 (JP), filed on Aug. 10, 2018.
Prior Publication US 2024/0141439 A1, May 2, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C12Q 1/6886 (2018.01)
CPC C12Q 1/6886 (2013.01) [C12Q 2600/158 (2013.01); C12Q 2600/178 (2013.01)] 6 Claims
 
1. A method for detecting prostate cancer and then treating or performing a diagnostic procedure in a human subject, comprising:
measuring an expression level of hsa-miR-6076 in a blood, serum, or plasma sample from the subject;
comparing the measured expression level of hsa-miR-6076 to a control expression level in a sample from a healthy subject; and
detecting an increased level of hsa-miR-6076 in the sample from the subject as compared to the control expression level from the sample from the healthy subject;
wherein the increased level of hsa-miR-6076 indicates that the subject has prostate cancer;
and further treating the subject for the prostate cancer or performing a diagnostic procedure on the subject with the prostate cancer;
wherein the treating comprises surgery, radiotherapy, chemotherapy or the combination thereof; and
wherein the diagnostic procedure comprises rectal examination, transrectal ultrasonography of the prostate, or imaging of prostate tissue.