US 12,252,582 B2
Biofunctional thiophene monomers and polymers thereof for electronic biomedical devices
David C. Martin, Lincoln University, PA (US); Samadhan Suresh Nagane, Maharashtra (IN); and Peter Sitarik, Fleetwood, PA (US)
Assigned to University Of Delaware, Newark, DE (US)
Appl. No. 17/637,108
Filed by David C. Martin, Lincoln University, PA (US); Samadhan Suresh Nagane, Maharashtra (IN); and Peter Sitarik, Fleetwood, PA (US)
PCT Filed Aug. 28, 2020, PCT No. PCT/US2020/048495
§ 371(c)(1), (2) Date Feb. 22, 2022,
PCT Pub. No. WO2021/041874, PCT Pub. Date Mar. 4, 2021.
Claims priority of provisional application 62/893,248, filed on Aug. 29, 2019.
Prior Publication US 2022/0289902 A1, Sep. 15, 2022
Int. Cl. C08G 61/12 (2006.01); C07D 495/04 (2006.01); C07D 519/00 (2006.01); C07J 33/00 (2006.01); H01B 1/12 (2006.01)
CPC C08G 61/126 (2013.01) [C07D 495/04 (2013.01); C07D 519/00 (2013.01); C07J 33/002 (2013.01); H01B 1/124 (2013.01); C08G 2261/122 (2013.01); C08G 2261/1424 (2013.01); C08G 2261/1426 (2013.01); C08G 2261/1428 (2013.01); C08G 2261/1432 (2013.01); C08G 2261/148 (2013.01); C08G 2261/334 (2013.01); C08G 2261/44 (2013.01); C08G 2261/94 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A biofunctionalized 3,4-alkylenedioxythiophene monomer represented by a chemical formula (C1R1R2)(C2R3R4)(C3R5R6)xO2C4H2S (A′DOT+, where A′ represents C1R1R2)(C2R3R4)(C3R5R6)x),
wherein x=0 or 1, when x=0, the functionalized 3,4-alkylenedioxythiophene monomer is 3,4-ethylenedioxythiophene (E′DOT+; where E′ represents C1R1R2)(C2R3R4)) and when x=1, the functionalized 3,4-alkylenedioxythiophene monomer is functionalized 3,4-propylenedioxythiophene (Pro′DOT+; where Pro′ represents C1R1R2)(C2R3R4)(C3R5R6)),
wherein each of R1, R2, R3, R4, R5, and R6 is independently selected from hydrogen, a hydrocarbyl group, and a heteroatom-containing functional group,
wherein one of C1, C2, or C3 is bonded to an amide group, an ester group or a

OG Complex Work Unit Chemistry
 group of a biofunctional hydrocarbyl moiety directly or through the hydrocarbyl group, and
wherein the biofunctional hydrocarbyl moiety is selected from adamantane, L-cysteine hydrochloride, L-tyrosine, dopamine, tyramine, norepinephrine, 3-methoxytyramine, polyethylene glycol, and polyethylene glycol amine.