US 12,252,528 B2
Compositions and methods for modulating Factor VIII function
Valder R. Arruda, Philadelphia, PA (US); and Benjamin Samelson-Jones, Wynnewood, PA (US)
Assigned to THE CHILDREN'S HOSPITAL OF PHILADELPHIA, Philadelphia, PA (US)
Appl. No. 17/279,961
Filed by THE CHILDREN'S HOSPITAL OF PHILADELPHIA, Philadelphia, PA (US)
PCT Filed Oct. 23, 2019, PCT No. PCT/US2019/057609
§ 371(c)(1), (2) Date Mar. 25, 2021,
PCT Pub. No. WO2020/086686, PCT Pub. Date Apr. 30, 2020.
Claims priority of provisional application 62/749,182, filed on Oct. 23, 2018.
Prior Publication US 2022/0033475 A1, Feb. 3, 2022
Int. Cl. C07K 14/755 (2006.01); A61K 38/00 (2006.01)
CPC C07K 14/755 (2013.01) [A61K 38/00 (2013.01)] 27 Claims
OG exemplary drawing
 
5. A Factor VIII (FVIII) variant, wherein said FVIII variant comprises amino acids 1-740 and 1649-2332 of SEQ ID NO: 1, except (i) wherein the Lys at position 659 is substituted with another amino acid, and (ii) wherein the amino acids at positions 560, 561, 712, and 713 may be optionally substituted with another amino acid.