	US 12,252,519 B2
	Crystal structure of a replication protein encoded by a plasmid isolated from a multiple sclerosis patient
Timo Bund, Dossenheim (DE); Grant S. Hansman, Heidelberg (DE); Turgay Kilic, Heidelberg (DE); Alexander N. Popov, Grenoble (FR); Ethel-Michele De Villiers-Zur Hausen, Waldmichelbach (DE); and Harald Zur Hausen, Waldmichelbach (DE)
Assigned to DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS, Heidelberg (DE)
Filed by DEUTSCHES KREBSFORSCHUNGSZENTRUM STIFTUNG DES ÖFFENTLICHEN RECHTS, Heidelberg (DE)
Filed on Apr. 27, 2021, as Appl. No. 17/242,116.
Application 17/242,116 is a continuation of application No. PCT/EP2019/081364, filed on Nov. 14, 2019.
Claims priority of application No. 18206532 (EP), filed on Nov. 15, 2018.
Prior Publication US 2021/0246178 A1, Aug. 12, 2021
Int. Cl. C07K 14/47 (2006.01); G01N 33/68 (2006.01); G16B 35/20 (2019.01)

CPC C07K 14/4703 (2013.01) [G01N 33/6893 (2013.01); G16B 35/20 (2019.02); C07K 2299/00 (2013.01)]

6 Claims

1. A crystal form of MSBI1.176 Rep protein having the amino acid sequence of SEQ ID NO: 1, characterized as having (a) a space group of P21 and (b) unit cell dimensions of a=32.38 Å±1-2 Å, b=77.77 Å±1-2 Å and c=47.68 Å±1-2 Å, α=90°, β=90.66° and γ=90°.