US 12,252,506 B2
Methods of preparing nicotinamide riboside and derivatives thereof
Marie Migaud, Lurgan (GB); Philip Redpath, Portadown (GB); Kerri Crossey, Magherafelt (GB); and Mark Doherty, Newtownabbey (GB)
Assigned to The Queen's University of Belfast, Belfast (GB)
Filed by The Queen's University of Belfast, Belfast (GB)
Filed on Apr. 26, 2023, as Appl. No. 18/307,733.
Application 18/307,733 is a continuation of application No. 17/736,834, filed on May 4, 2022, granted, now 11,981,698.
Application 17/736,834 is a continuation of application No. 16/886,985, filed on May 29, 2020, granted, now 11,584,770, issued on Feb. 21, 2023.
Application 16/886,985 is a continuation of application No. 15/905,922, filed on Feb. 27, 2018, granted, now 10,815,262, issued on Oct. 27, 2020.
Application 15/905,922 is a continuation of application No. 14/908,831, granted, now 10,000,519, issued on Jun. 19, 2018, previously published as PCT/EP2014/065971, filed on Jul. 24, 2014.
Claims priority of application No. 1313465 (GB), filed on Jul. 29, 2013.
Prior Publication US 2024/0101588 A1, Mar. 28, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. C07H 19/048 (2006.01); C07H 1/00 (2006.01); C07H 1/06 (2006.01); C07H 19/04 (2006.01)
CPC C07H 19/048 (2013.01) [C07H 1/00 (2013.01); C07H 1/06 (2013.01); C07H 19/04 (2013.01); Y02P 20/582 (2015.11)] 43 Claims
 
1. A compound of formula (IV):

OG Complex Work Unit Chemistry
or the beta-anomer thereof,
where:
n is 0 and Y is absent;
m is 1;
R1 is a substituted or unsubstituted primary amino;
R2-R5 are each H;
R6, R7 and R8, which may be the same or different, are each independently H or a hydroxyl-protecting group; or wherein R6 is a phosphate; and
X− is an anion selected from an anion of a substituted carboxylic acid, an anion of an unsubstituted carboxylic acid other than an anion of formic acid, an anion of a substituted or unsubstituted phosphate, an anion of a substituted or unsubstituted sulfate, an anion of a substituted or unsubstituted carbonate, and an anion of a substituted or unsubstituted carbamate.