US 12,252,487 B2
Dominant salt forms of pyrimidine derivatives, and crystal forms thereof
Xiaoxin Chen, Guangzhou (CN); Chengwu Liu, Guangzhou (CN); Zhuowei Liu, Guangzhou (CN); Zhenyou Tan, Guangzhou (CN); Zhiqiang Liu, Guangzhou (CN); Zhiwei Cheng, Guangzhou (CN); Chaofeng Long, Guangzhou (CN); Jiajun Huang, Guangzhou (CN); and Guangqiang Zhou, Guangzhou (CN)
Assigned to GUANGDONG RAYNOVENT BIOTECH CO., LTD., Guangzhou (CN)
Appl. No. 17/628,496
Filed by GUANGDONG RAYNOVENT BIOTECH CO., LTD., Guangzhou (CN)
PCT Filed Jun. 24, 2020, PCT No. PCT/CN2020/097967
§ 371(c)(1), (2) Date Jan. 19, 2022,
PCT Pub. No. WO2021/012864, PCT Pub. Date Jan. 28, 2021.
Claims priority of application No. 201910660153.1 (CN), filed on Jul. 22, 2019.
Prior Publication US 2022/0380363 A1, Dec. 1, 2022
Int. Cl. C07D 471/04 (2006.01)
CPC C07D 471/04 (2013.01) [C07B 2200/13 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A crystal form of Compound 1, comprising a crystal form I, a crystal form II, a crystal form III, a crystal form IV, a crystal form V, a crystal form VII or a crystal form VIII,

OG Complex Work Unit Chemistry
wherein,
(i) an XRPD pattern of the crystal form I of Compound 1 has diffraction peaks at angles 2θ of 6.4, 9.8, 12.8, 15.8, 16.2, 17.8, 18.7, 19.3, 20.3, 24.0, 24.6, 27.6, 28.1±0.2°;
(ii) an XRPD pattern of the crystal form II of Compound 1 has diffraction peaks at angles 2θ of 5.8, 9.3, 10.0, 11.6, 13.7, 17.0, 18.9, 22.8, 24.2±0.2°;
(iii) an XRPD pattern of the crystal form III of Compound 1 has diffraction peaks at angles 2θ of 4.6, 5.4, 7.1, 9.7, 10.8, 12.4, 15.1, 17.0, 17.8, 18.9, 19.6, 20.7, 21.8, 23.7, 25.0±0.2°;
(iv) an XRPD pattern of the crystal form IV of Compound 1 has diffraction peaks at angles 2θ of 5.7, 6.9, 9.3, 12.3, 14.3, 16.7, 17.8, 18.7, 19.3, 20.6, 23.8, 28.4±0.2°;
(v) an XRPD pattern of the crystal form V of Compound 1 has diffraction peaks at angles 2θ of 7.1, 9.4, 12.3, 15.5, 18.8, 19.8, 20.9, 25.5, 27.1±0.2°;
(vi) an XRPD pattern of the crystal form VII of Compound 1 has diffraction peaks at angles 2θ of 4.6, 5.8, 7.3, 7.8, 11.3, 14.6, 18.4±0.2°; and
(vii) an XRPD pattern of the crystal form VIII of Compound 1 has diffraction peaks at angles 2θ of 6.0, 7.0, 7.6, 11.0, 12.2, 14.1, 14.4, 15.4, 18.7, 20.0, 27.8±0.2°.