US 12,252,483 B2
Method for producing optically active 1, 4-benzothiazepine-1-oxide derivative
Sayuri Hirano, Osaka (JP)
Assigned to AETAS PHARMA CO., LTD., Tokyo (JP)
Appl. No. 17/628,979
Filed by AETAS PHARMA CO., LTD., Tokyo (JP)
PCT Filed Jul. 22, 2020, PCT No. PCT/JP2020/028375
§ 371(c)(1), (2) Date May 17, 2022,
PCT Pub. No. WO2021/015221, PCT Pub. Date Jan. 28, 2021.
Claims priority of application No. 2019-134766 (JP), filed on Jul. 22, 2019.
Prior Publication US 2022/0324856 A1, Oct. 13, 2022
Int. Cl. C07D 417/06 (2006.01)
CPC C07D 417/06 (2013.01) 18 Claims
 
1. A method for producing an optically active compound of the Formula (IV) or a salt thereof,

OG Complex Work Unit Chemistry
wherein * indicates the presence of optical isomers, and R represents a hydrogen atom or a hydroxyl group,
wherein the method comprises the following process:
a process of allowing a compound of the Formula (III) or a salt thereof to react with a reactant containing a titanium compound, a chiral diol compound, and water, and an oxidant in a solvent,

OG Complex Work Unit Chemistry
wherein R represents a hydrogen atom or a hydroxyl group.