US 12,252,480 B2
Salt forms and polymorphs of (R)-1-(4-(6-(2-(4-(3,3-difluorocyclobutoxy)-6-methylpyridin-2-yl)acetamido) pyridazin-3-yl)-2-fluorobutyl)-n-methyl-1H-1,2,3-triazole-4-carboxamide
Philip Jones, Houston, TX (US); Michael J. Soth, Sugar Land, TX (US); Jason P. Burke, Houston, TX (US); Kang Le, Sugar Land, TX (US); and Gang Liu, Sugar Land, TX (US)
Assigned to Board of Regents, The University of Texas System, Austin, TX (US)
Filed by Board of Regents, The University of Texas System, Austin, TX (US)
Filed on Feb. 1, 2023, as Appl. No. 18/163,151.
Application 16/172,506 is a division of application No. 15/387,560, filed on Dec. 21, 2016, granted, now 10,150,753, issued on Dec. 11, 2018.
Application 18/163,151 is a continuation of application No. 17/124,051, filed on Dec. 16, 2020, granted, now 11,603,365.
Application 17/124,051 is a continuation of application No. 16/241,596, filed on Jan. 7, 2019, granted, now 10,899,740, issued on Jan. 26, 2021.
Application 16/241,596 is a continuation of application No. 16/172,506, filed on Oct. 26, 2018, abandoned.
Claims priority of provisional application 62/271,018, filed on Dec. 22, 2015.
Prior Publication US 2023/0250081 A1, Aug. 10, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 401/14 (2006.01); A61K 31/337 (2006.01); A61K 31/501 (2006.01); A61K 45/06 (2006.01); A61P 35/00 (2006.01)
CPC C07D 401/14 (2013.01) [A61K 31/337 (2013.01); A61K 31/501 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07B 2200/13 (2013.01)] 10 Claims
 
1. A process for preparing a crystalline compound of structural formula

OG Complex Work Unit Chemistry
comprising slurrying the solid compound with a solvent or a mixture of solvents to remove amorphous compound and isolating the crystalline compound.