	US 12,252,473 B2
	Preparation methods of quinolone compounds and intermediates thereof
Jie Lei, Chongqing (CN); Zhongzhu Chen, Chongqing (CN); Zhigang Xu, Chongqing (CN); Dianyong Tang, Chongqing (CN); Jiayu Xu, Chongqing (CN); Haoyi Zhou, Chongqing (CN); Dandan Xia, Chongqing (CN); Yao Liu, Chongqing (CN); Yihua Cao, Chongqing (CN); and Jie Luo, Chongqing (CN)
Assigned to Chongqing University of Arts and Sciences, Chongqing (CN)
Appl. No. 18/261,960
Filed by Chongqing University of Arts and Sciences, Chongqing (CN)
PCT Filed May 5, 2022, PCT No. PCT/CN2022/090989 § 371(c)(1), (2) Date Jul. 18, 2023, PCT Pub. No. WO2023/201780, PCT Pub. Date Oct. 26, 2023.
Claims priority of application No. 202210437152.2 (CN), filed on Apr. 18, 2022.
Prior Publication US 2024/0400522 A1, Dec. 5, 2024
Int. Cl. C07D 241/04 (2006.01); C07D 213/74 (2006.01); C07D 221/04 (2006.01); C07D 491/056 (2006.01)

CPC C07D 241/04 (2013.01) [C07D 213/74 (2013.01); C07D 221/04 (2013.01); C07D 491/056 (2013.01)]

12 Claims

1. A process for the preparation of a compound of Formula I, comprising the steps of:

reacting a compound of Formula A with R⁵NH₂and R⁶Cl in the presence of a base to form the compound of Formula I,

wherein:

X is selected from the group consisting of CR²and N;

Z is selected from the group consisting of CR⁴and N;

R¹is independently selected from the group consisting of hydrogen, alkyl, alkoxy, halo, NO₂, CN, optionally substituted amino, haloalkyl, aryl, and heteroaryl;

R²and R³are each independently selected from the group consisting of hydrogen, alkyl, alkoxy, halo, amino, NO₂, CN, haloalkyl, aryl, and heteroaryl; or R²and R³are linked together to form a ring;

R⁴is independently selected from the group consisting of hydrogen, alkyl, alkoxy, halo, amino, NO₂, CN, haloalkyl, aryl, and heteroaryl;

R⁵is independently selected from the group consisting of alkyl optionally substituted with OH or SH; cycloalkyl optionally substituted with halo; aryl; and heteroaryl; and

R⁶is independently selected from sulfonyl.