US 12,252,472 B1
Barbituric acid derivatives, their preparation and use thereof as leukocyte transmigration inhibitors and for treating inflammatory diseases, autoimmune diseases and cancer
Arie Lev Gruzman, Tzur Hadassah (IL); Paul Bradfield, Geneva (CH); Tamar Getter, Ashkelon (IL); Beat Imhof, Conches (CH); Thomas Matthes, Onex (CH); and Hanoch Senderowitz, Tel Aviv (IL)
Assigned to BAR-ILAN UNIVERSITY, Ramat Gan (IL); UNIVERSITY OF GENEVA, Geneva (CH); and GENEVA UNIVERSITY HOSPITALS, Geneva (CH)
Filed by BAR-ILAN UNIVERSITY, Ramat Gan (IL); UNIVERSITY OF GENEVA, Geneva (CH); and GENEVA UNIVERSITY HOSPITALS, Geneva (CH)
Filed on Sep. 30, 2022, as Appl. No. 17/957,549.
Application 17/957,549 is a division of application No. 16/642,496, granted, now 11,492,333, previously published as PCT/IL2018/050961, filed on Aug. 30, 2018.
Claims priority of provisional application 62/552,491, filed on Aug. 31, 2017.
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 239/62 (2006.01)
CPC C07D 239/62 (2013.01) 28 Claims
 
1. A compound selected from the compounds of Formula 1, Formula 5, Formula 6, Formula 7 and Formula 9:

OG Complex Work Unit Chemistry

OG Complex Work Unit Chemistry
 or
pharmaceutically acceptable salts thereof.
 
2. A pharmaceutical composition comprising one or more of compounds of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier and/or diluent.