US 12,252,471 B2
Isoquinoline compounds and their use in treating AhR imbalance
Channa K. Jayawickreme, Morrisville, NC (US); Susan H. Smith, Pennsburg, PA (US); Cunyu Zhang, Devon, PA (US); and William Zuercher, Mies (CH)
Assigned to DERMAVANT SCIENCES GMBH, Basel (CH)
Filed by Dermavant Sciences GmbH, Basel (CH)
Filed on Oct. 20, 2023, as Appl. No. 18/491,538.
Application 18/050,888 is a division of application No. 17/587,812, filed on Jan. 28, 2022, granted, now 11,548,853, issued on Jan. 10, 2023.
Application 17/587,812 is a division of application No. 17/332,805, filed on May 27, 2021, granted, now 11,267,788, issued on Mar. 8, 2022.
Application 18/491,538 is a continuation of application No. 18/050,888, filed on Oct. 28, 2022, granted, now 11,827,605, issued on Nov. 28, 2023.
Claims priority of provisional application 63/052,574, filed on Jul. 16, 2020.
Claims priority of provisional application 63/052,561, filed on Jul. 16, 2020.
Prior Publication US 2024/0208910 A1, Jun. 27, 2024
Int. Cl. C07D 217/20 (2006.01); A61K 9/00 (2006.01); A61K 31/47 (2006.01); A61P 29/00 (2006.01)
CPC C07D 217/20 (2013.01) [A61K 9/0014 (2013.01); A61K 31/47 (2013.01); A61P 29/00 (2018.01)] 7 Claims
OG exemplary drawing
 
1. A compound of Formula (I) or a salt, solvate or hydrate thereof,

OG Complex Work Unit Chemistry
wherein:
R1 is selected from the group consisting of OH and OR7, wherein R7 is selected from the group consisting of substituted C1-6 alkyl and C1-6 alkyl;
R2 is selected from the group consisting of OH and OR7, wherein R7 is selected from the group consisting of substituted C1-6 alkyl and C1-6 alkyl;
R3 is selected from the group consisting of substituted C1-6 alkyl and C1-6 alkyl;
R4 is selected from the group consisting of H, —(CR18R19)tCOOR8, and —(CR18R19)tC(O)NR9R10; wherein t is 0, R8 is selected from the group consisting of H substituted C1-6 alkyl and C1-6 alkyl, R9 is H and R10 is selected from the group consisting of substituted C1-6 alkyl and C1-6 alkyl;
R5 is H; and
R6 is selected from the group consisting of H and halo;
wherein the term substituted C1-6 alkyl, refers to a C1-6 alkyl substituted one or more times with a substituent independently selected from the group consisting of halo; hydroxy; hydroxy substituted C1-3 alkyl; C1-3 alkoxy; halo substituted C1-3 alkoxy; S(O)mC1-3 alkyl; NR22R23, wherein R22 and R23 are independently selected from H or C1-3 alkyl or wherein R22 and R23 together with the nitrogen to which they are attached form a 5 to 7 membered ring which optionally contains an additional heteroatom selected from O, N, or S; C1-3 alkyl; C3-7 cycloalkyl, or C3-7 cycloalkyl C1-3 alkyl group; halo substituted C1-3 alkyl; substituted aryl or substituted aryl C1-3 alkyl and wherein these aryl containing moieties may also be substituted one to two times by halo; hydroxy; hydroxy substituted C1-3 alkyl; C1-3 alkoxy; S(O)mC1-3 alkyl; amino, mono and di-substituted C1-3 alkylamino; C1-3 alkyl, or CF3.