filling a washed and depyrogenized glass container with a buffer for the pharmaceutical formulation, wherein the glass container comprises ions selected from the group comprising sodium, calcium, hydroxide, silicate, and combinations thereof;

storing the filled glass container at a temperature of 40° C. for at least 14 days;

optically analyzing the buffer after storage for formation of one or more particles in the buffer;

when particle formation is observed, isolating the one or more particles from the buffer for structural and elemental analysis;

analyzing the isolated one or more particles using one or more of optical microscopy, scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDS), Fourier-transform infrared spectroscopy (FTIR), x-ray photoelectron spectroscopy (XPS), differential interference contrast microscopy (DIC), microflow imaging (MFI), and combinations thereof to determine a morphology of the particles and chemical composition; and

analyzing an interior surface of the glass container, once emptied and after isolating the one or more particles, for delamination-type deformation of the interior surface, wherein the presence of particles having a chemical composition comprising silicon, oxygen, and carbon, and an absence of the delamination-type deformation of the interior surface of the glass container indicates the susceptibility to lamellar silica formation.