US 12,251,702 B2
Flowcell cartridge with floating seal bracket
David Elliott Kaplan, Carlsbad, CA (US); Anthony John de Ruyter, San Diego, CA (US); Richard Alan Kelley, San Diego, CA (US); and Ashish Kumar, San Diego, CA (US)
Assigned to Illumina, Inc., San Diego, CA (US)
Filed by Illumina, Inc., San Diego, CA (US)
Filed on Sep. 6, 2024, as Appl. No. 18/827,174.
Application 18/167,836 is a division of application No. 16/777,881, filed on Jan. 30, 2020, granted, now 11,577,253, issued on Feb. 14, 2023.
Application 16/777,881 is a division of application No. 16/436,485, filed on Jun. 10, 2019, granted, now 10,549,282, issued on Feb. 4, 2020.
Application 18/827,174 is a continuation of application No. 18/167,836, filed on Feb. 11, 2023, granted, now 12,097,502.
Application 16/436,485 is a continuation of application No. 15/841,109, filed on Dec. 13, 2017, granted, now 10,357,775, issued on Jul. 23, 2019.
Claims priority of provisional application 62/441,927, filed on Jan. 3, 2017.
Claims priority of application No. 1704769 (GB), filed on Mar. 24, 2017.
Prior Publication US 2024/0424500 A1, Dec. 26, 2024
Int. Cl. B01L 9/00 (2006.01); B01L 3/00 (2006.01)
CPC B01L 9/527 (2013.01) [B01L 3/502715 (2013.01); B01L 2200/025 (2013.01); B01L 2200/027 (2013.01); B01L 2200/04 (2013.01); B01L 2200/0689 (2013.01); B01L 2300/041 (2013.01); B01L 2300/0609 (2013.01); B01L 2300/0809 (2013.01); B01L 2300/0816 (2013.01); B01L 2300/0822 (2013.01); B01L 2300/0877 (2013.01)] 11 Claims
OG exemplary drawing
 
1. A microfluidic cartridge comprising:
a frame;
a microfluidic plate positioned within the frame, wherein the microfluidic plate floats relative to the frame, the microfluidic plate comprising a first side, a first edge, and a plurality of first fluidic ports located in the first side;
a support bracket positioned within the frame, wherein the support bracket floats relative to the microfluidic plate and the frame, the support bracket comprising:
a plurality of seals supported by the support bracket, each seal of the plurality of seals positioned to interface with a corresponding first fluidic port of the plurality of first fluidic ports, and
a plurality of alignment holes corresponding to a first plurality of indexing features located on an analysis device, the plurality of alignment holes configured to align the plurality of seals with corresponding analysis device ports located on the analysis device; and
wherein the frame includes a plurality of apertures proximate the first edge of the microfluidic plate, the plurality of apertures corresponding to a second plurality of indexing features located on the analysis device, and
wherein the second plurality of indexing features engage the microfluidic plate and the first plurality of indexing features engage the plurality of alignment holes to align the plurality of first fluidic ports, the plurality of seals, and the second fluidic ports when the microfluidic cartridge is installed in the analysis device.