| CPC A61M 1/029 (2013.01) [A61M 1/0272 (2013.01); A61M 1/0281 (2013.01); A61M 1/67 (2021.05)] | 18 Claims | 

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               1. A screen exchange device comprising: 
            a disk comprising a plurality of screens, each having at least one through-hole to reduce a size of a biological tissue, the screens having different through-hole characteristics; 
                a first cover that covers a first side of the disk and comprises a first opening through which a biological tissue passes; 
                a second cover that covers a second side of the disk and comprises a second opening through which the biological tissue passes; 
                a housing configured to receive the disk, the first cover and the second cover; and 
                a manipulator configured to select a screen from the plurality of screens and manipulate the first cover or the second cover such that the selected screen communicates with the first opening and the second opening, wherein the manipulator is disposed inside the housing, 
                wherein the manipulator comprises: 
              a first handle configured to rotate the first cover relative to the disk; and 
                  a second handle configured to rotate the second cover relative to the disk. 
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