	US 12,251,490 B2
	Composition of alpha-TCP, silicate and phosphorylated amino acid
Philip Procter, Divonne les Bains (FR); Håkan Engqvist, Uppsala (SE); Michael Pujari-Palmer, Uppsala (SE); and Gerard Insley, Limerick (IE)
Assigned to BIOMIMETIC INNOVATIONS LIMITED, (IE)
Appl. No. 16/337,355
Filed by GPBIO LTD., Limerick (IE)
PCT Filed Sep. 27, 2017, PCT No. PCT/EP2017/074551 § 371(c)(1), (2) Date Mar. 27, 2019, PCT Pub. No. WO2018/060287, PCT Pub. Date Apr. 5, 2018.
Claims priority of application No. 1651271-7 (SE), filed on Sep. 27, 2016.
Prior Publication US 2020/0038545 A1, Feb. 6, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61L 24/02 (2006.01); A61B 17/00 (2006.01); A61K 6/30 (2020.01); A61L 24/00 (2006.01); A61L 27/12 (2006.01); A61L 27/52 (2006.01)

CPC A61L 24/02 (2013.01) [A61B 17/00491 (2013.01); A61K 6/30 (2020.01); A61L 24/0031 (2013.01); A61L 27/12 (2013.01); A61L 27/52 (2013.01); A61B 2017/00495 (2013.01); A61B 2017/005 (2013.01); A61L 2400/06 (2013.01); A61L 2430/34 (2013.01)]

23 Claims

1. An aqueous composition comprising an aqueous solution, a silicate compound, α-TCP and a phosphorylated amino acid;

wherein the amount of phosphorylated amino acid is 20-50 wt % of the solid content, the combined amount of silicate compound and α-TCP is 10-80 wt % of the solid content, wherein the weight ratio of the silicate compound to α-TCP is 1:1-50; wherein the silicate compound is a mixture of di- and tricalcium silicate; and wherein the composition has a shear strength to bone of at least 1.5 MPa when measured after 24 h of curing at 100% humidity and 37 C.