US 12,251,469 B2
Sterically stabilized carrier compositions for treating a mammal
Kameswari S. Konduri, Madison, WI (US); Nejat Duzgunes, Mill Valley, CA (US); Jogi Pattisapu, Orlando, FL (US); and Ram Pattisapu, Silverthorne, CO (US)
Assigned to VGSK Technologies, Inc., Madison, WI (US)
Filed by VGSK Technologies, Inc., Madison, WI (US)
Filed on Jan. 3, 2024, as Appl. No. 18/403,360.
Application 18/403,360 is a continuation of application No. 17/571,049, filed on Jan. 7, 2022, abandoned.
Application 17/571,049 is a continuation of application No. 15/759,651, abandoned, previously published as PCT/US2016/051759, filed on Sep. 14, 2016.
Claims priority of provisional application 62/218,558, filed on Sep. 14, 2015.
Prior Publication US 2024/0180835 A1, Jun. 6, 2024
Int. Cl. A61K 9/127 (2006.01); A61K 9/1271 (2025.01); A61K 31/573 (2006.01); A61K 31/58 (2006.01); A61K 45/06 (2006.01); A61K 47/34 (2017.01); A61P 29/00 (2006.01); A61P 31/06 (2006.01); A61P 37/08 (2006.01)
CPC A61K 9/1271 (2013.01) [A61K 9/127 (2013.01); A61K 31/573 (2013.01); A61K 31/58 (2013.01); A61K 45/06 (2013.01); A61K 47/34 (2013.01); A61P 29/00 (2018.01); A61P 31/06 (2018.01); A61P 37/08 (2018.01)] 20 Claims
 
1. A method for treating inflammation associated with an allergy or a disease in a subject in need thereof, the method comprising administering, orally or sublingually, (1) a first active agent encapsulated in a first liposome carrier that comprises: i) poly (ethylene glycol) distearoylphosphatidylethanolamine (PEG-DSPE), ii) phosphatidylglycerol, phosphatidylcholine, or a combination thereof, and iii) a pH sensitive component which causes the liposome to release the first active agent in a pH range of about pH 1 to about pH 5; and (2) a second active agent encapsulated in a second liposome carrier that comprises: i) poly (ethylene glycol) distearoylphosphatidylethanolamine (PEG-DSPE), ii) phosphatidylglycerol, phosphatidylcholine, or a combination thereof, wherein the second liposome carrier releases the second active agent in a pH range of about pH 6 to about pH 8.