US 12,251,457 B2
Self-neutralizing amino acid based cationic compositions
Rocco V. Burgo, Mullica Hill, NJ (US); Mei Chen, Philadelphia, PA (US); Michael J. Fevola, Belle Meade, NJ (US); Gary Mosser, Tabernacle, NJ (US); and Brittany Pease, Philadelphia, PA (US)
Assigned to INOLEX INVESTMENT CORPORATION, Wilmington, DE (US)
Filed by Inolex Investment Corporation, Wilmington, DE (US)
Filed on Nov. 28, 2022, as Appl. No. 18/070,021.
Application 18/070,021 is a continuation of application No. 16/813,475, filed on Mar. 9, 2020, granted, now 11,540,991.
Claims priority of provisional application 62/815,314, filed on Mar. 7, 2019.
Prior Publication US 2023/0092150 A1, Mar. 23, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 8/44 (2006.01); A61K 8/64 (2006.01); A61K 8/81 (2006.01); A61Q 5/12 (2006.01)
CPC A61K 8/44 (2013.01) [A61K 8/64 (2013.01); A61K 8/8141 (2013.01); A61Q 5/12 (2013.01); A61K 2800/5426 (2013.01)] 23 Claims
 
1. An aqueous formulation comprising a self-neutralizing amino acid-based cationic composition and water, the self-neutralizing amino acid-based cationic composition comprising:
an amino acid-based cationic ester of formula (I):

OG Complex Work Unit Chemistry
 where R1 is a branched or linear alkyl group having 1 to 10 carbon atoms, R2 is a linear or branched carbon chain having 10 to 50 carbon atoms, where X− represents a conjugate base,
an anhydrous buffering agent comprising a salt formed from a strong base and a weak organic acid,
wherein a ratio of anhydrous buffering agent to amino acid-based cationic ester in the self-neutralizing amino acid-based cationic composition is about 1:2 to about 1:8 on a weight basis, and
a nonionic amphiphile;
wherein the formulation comprises about 5 wt % to about 20 wt % of the self-neutralizing amino acid-based cationic composition, wherein the anhydrous buffering agent is the sole buffering agent in the formulation, and
wherein the formulation is a lamellar liquid crystal system having a d-spacing of about 1 nm to about 100 nm as measured by small-angle X-ray scattering (SAXS).