US 12,251,456 B2
Methods for treating relaxed hair
Eric D. Pressly, Santa Barbara, CA (US); and Craig J. Hawker, Santa Barbara, CA (US)
Assigned to OLAPLEX, INC., Boston, MA (US)
Filed by Olaplex, Inc., Boston, MA (US)
Filed on Dec. 3, 2021, as Appl. No. 17/542,112.
Application 15/341,893 is a division of application No. 15/137,788, filed on Apr. 25, 2016, granted, now 9,597,273, issued on Mar. 21, 2017.
Application 17/542,112 is a continuation of application No. 16/571,933, filed on Sep. 16, 2019, granted, now 11,191,707.
Application 16/571,933 is a continuation of application No. 15/626,453, filed on Jun. 19, 2017, abandoned.
Application 15/626,453 is a continuation of application No. 15/341,893, filed on Nov. 2, 2016, granted, now 9,717,668, issued on Aug. 1, 2017.
Claims priority of provisional application 62/152,220, filed on Apr. 24, 2015.
Prior Publication US 2022/0323327 A1, Oct. 13, 2022
Int. Cl. A61K 8/41 (2006.01); A45D 7/00 (2006.01); A45D 7/04 (2006.01); A61K 8/19 (2006.01); A61K 8/36 (2006.01); A61K 8/362 (2006.01); A61K 8/46 (2006.01); A61Q 5/02 (2006.01); A61Q 5/04 (2006.01); A61Q 5/12 (2006.01)
CPC A61K 8/416 (2013.01) [A45D 7/00 (2013.01); A45D 7/04 (2013.01); A61K 8/19 (2013.01); A61K 8/36 (2013.01); A61K 8/362 (2013.01); A61K 8/41 (2013.01); A61K 8/46 (2013.01); A61K 8/466 (2013.01); A61Q 5/02 (2013.01); A61Q 5/04 (2013.01); A61Q 5/12 (2013.01); A61K 2800/59 (2013.01); A61K 2800/882 (2013.01); A61K 2800/884 (2013.01)] 19 Claims
 
1. A method for achieving a desired level of curl in hair comprising:
(a) applying to the hair one or more relaxing agents at an alkaline pH; and
(b) applying to the hair an active agent of Formula III:
(B)m-Z-(A)n-(C)o  Formula III
wherein Z is a linker or is absent;
wherein m and n are each an integer independently selected from 1-6, provided that m+n is at least 2;
wherein group A is an ionizable functional group;
wherein group B is selected from the group consisting of:

OG Complex Work Unit Chemistry
wherein each R is independently selected from hydrogen, C1-6 alkyl, aryl, or an ionizable functional group; Z′ is oxygen (O), NH, or is absent; and G is carbon (C) and g is 1, or G is sulfur (S) and g is 2;
wherein group C is an ionic group capable of forming a covalent bond with a thiol;
wherein group C is ionically bonded to group A and has a charge opposite the charge of A;
wherein o is an integer value selected from 1-6, provided that the sum of charges of groups A and C is zero;
wherein the one or more relaxing agents cause the hair to relax;
wherein the active agent is present in an effective amount to retain a level of curl (percent curl retention) in the treated hair in the range of about 0-99%, compared to the amount of curl in the hair prior to step (a); and
wherein steps (a) and (b) are performed simultaneously.