US 12,251,451 B2
Emulsion for ultrasound ablation surgery
Christiane Contino-Pepin, Althen des Paluds (FR); Stéphane Desgranges, Avignon (FR); and Nicolas Taulier, Paris (FR)
Assigned to Avignon Université, Avignon (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, Paris (FR); INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, Paris (FR); Sorbonne Université, Paris (FR); UNIVERSITE DE MONTPELLIER, Montpellier (FR); and ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER, Montpellier (FR)
Appl. No. 17/252,100
Filed by AVIGNON UNIVERSITE, Avignon (FR); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, Paris (FR); INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE, Paris (FR); SORBONNE UNIVERSITE, Paris (FR); UNIVERSITE DE MONTPELLIER, Montpellier (FR); and ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER, Montpellier (FR)
PCT Filed Jun. 14, 2019, PCT No. PCT/EP2019/065757
§ 371(c)(1), (2) Date Dec. 14, 2020,
PCT Pub. No. WO2019/238956, PCT Pub. Date Dec. 19, 2019.
Claims priority of application No. 1855237 (FR), filed on Jun. 14, 2018.
Prior Publication US 2021/0252172 A1, Aug. 19, 2021
Int. Cl. A61K 49/18 (2006.01); A61K 9/00 (2006.01); A61K 49/10 (2006.01); A61N 7/00 (2006.01)
CPC A61K 49/1806 (2013.01) [A61K 9/0009 (2013.01); A61K 9/0019 (2013.01); A61K 49/10 (2013.01); A61N 7/00 (2013.01)] 13 Claims
 
1. An injectable emulsion comprising:
a first phase comprising droplets including at least one perfluorocarbon compound;
a second phase, which is aqueous; and
an amphiphilic compound;
wherein the droplets have a diameter d4,3 of between 1 μm and 5.5 μm;
wherein the amphiphilic compound comprises a dendrimer of Dendri-TAC type;
wherein a concentration by volume of the first phase in the second phase is between 0.001% v/v and 0.3% v/v; and
wherein the at least one perfluorocarbon compound has a boiling point above 100° C.