US 12,251,417 B2
Antimicrobial compounds from the genus Delftia
Israel Nissan, Modiln (IL); Noa Lea Tejman-Yarden, Tel-Aviv (IL); Chaim Rubinovitz, Omer (IL); Yakov Davidov, Jerusalem (IL); Galia Rahav, Jerusalem (IL); Ari Robinson, Bnei-Atarot (IL); and Yoram Shotland, LeHavim (IL)
Assigned to Ministry of Health, State of Israel, Jerusalem (IL); Sami Shamoon College of Engineering (R.A), Beer-Sheva (IL); and Tel HaShomer Medical Research lnfrastructure and Services Ltd., Ramat-Gan (IL)
Filed by Ministry of Health, State of Israel, Jerusalem (IL); Sami Shamoon College of Engineering (R.A), Beer-Sheva (IL); and Tel HaShomer Medical Research Infrastructure and Services Ltd., Ramat-Gan (IL)
Filed on Dec. 13, 2021, as Appl. No. 17/548,662.
Application 17/548,662 is a division of application No. 16/496,978, granted, now 11,197,907, previously published as PCT/IL2018/050363, filed on Mar. 28, 2018.
Claims priority of provisional application 62/477,493, filed on Mar. 28, 2017.
Prior Publication US 2022/0096591 A1, Mar. 31, 2022
Int. Cl. A61K 38/08 (2019.01); A61K 33/242 (2019.01); A61K 45/06 (2006.01); A61P 31/04 (2006.01); C12N 1/20 (2006.01); C12P 21/02 (2006.01)
CPC A61K 38/08 (2013.01) [A61K 33/242 (2019.01); A61P 31/04 (2018.01); C12N 1/20 (2013.01); C12P 21/02 (2013.01); A61K 45/06 (2013.01)] 4 Claims
 
1. A composition comprising isolated Delftibactin A or isolated Delftibactin B and an antibiotic selected from the group consisting of Daptomycin; Gemifloxacin; Telavancin; Ceftaroline; Fidaxomicin; Amoxicillin; Ampicillin; Bacampicillin; Carbenicillin; Cloxacillin; Dicloxacillin; Flucloxacillin; Mezlocillin; Nafcillin; Oxacillin; Penicillin G; Penicillin V; Piperacillin; Pivampicillin; Pivmecillinam; Ticarcillin; Aztreonam; Imipenem; Doripenem; Meropenem; Ertapenem; Clindamycin; Lincomycin; Pristinamycin; Quinupristin; Cefacetrile (cephacetrile); Cefadroxil (cefadroxyl); Cefalexin (cephalexin); Cefaloglycin (cephaloglycin); Cefalonium (cephalonium); Cefaloridine (cephaloradine); Cefalotin (cephalothin); Cefapirin (cephapirin); Cefatrizine; Cefazaflur; Cefazedone; Cefazolin (cephazolin); Cefradine (cephradine); Cefroxadine; Ceftezole; Cefaclor; Cefamandole; Cefmetazole; Cefonicid; Cefotetan; Cefoxitin; Cefprozil (cefproxil); Cefuroxime; Cefuzonam; Cefcapene; Cefdaloxime; Cefdinir; Cefditoren; Cefetamet; Cefixime; Cefmenoxime; Cefodizime; Cefotaxime; Cefpimizole; Cefpodoxime; Cefteram; Ceftibuten; Ceftiofur; Ceftiolene; Ceftizoxime; Ceftriaxone; Cefoperazone; Ceftazidime; Cefclidine; Cefepime; Cefluprenam; Cefoselis; Cefozopran; Cefpirome; Cefquinome; Ceftobiprole; Ceftaroline; Cefaclomezine; Cefaloram; Cefaparole; Cefcanel; Cefedrolor; Cefempidone; Cefetrizole; Cefivitril; Cefmatilen; Cefmepidium; Cefovecin; Cefoxazole; Cefrotil; Cefsumide; Cefuracetime; Ceftioxide; Azithromycin; Erythromycin; Clarithromycin; Dirithromycin; Roxithromycin; Telithromycin; Amikacin; Gentamicin; Kanamycin; Neomycin; Netilmicin; Paromomycin; Streptomycin; Tobramycin; Flumequine; Nalidixic acid; Oxolinic acid; Piromidic acid; Pipemidic acid; Rosoxacin; Ciprofloxacin; Enoxacin; Lomefloxacin; Nadifloxacin; Norfloxacin; Ofloxacin; Pefloxacin; Rufloxacin; Balofloxacin; Gatifloxacin; Grepafloxacin; Levofloxacin; Moxifloxacin; Pazufloxacin; Sparfloxacin; Temafloxacin; Tosufloxacin; Besifloxacin; Clinafloxacin; Gemifloxacin; Sitafloxacin; Trovafloxacin; Prulifloxacin; Sulfamethizole; Sulfamethoxazole; Sulfisoxazole; Trimethoprim-Sulfamethoxazole; Demeclocycline; Doxycycline; Minocycline; Oxytetracycline; Tetracycline; Tigecycline; Chloramphenicol; Metronidazole; Tinidazole; Nitrofurantoin; Vancomycin; Teicoplanin; Telavancin; Linezolid; Cycloserine 2; Rifampin; Rifabutin; Rifapentine; Bacitracin; Polymyxin B; Viomycin and Capreomycin.