US 12,251,401 B2
Synthesis and antimicrobial uses of dinuclear silver(I) pyrazolates
Raphael G. Raptis, Miami, FL (US); Indranil Chakraborty, Miami, FL (US); and Shambhu Kandel, Miami, FL (US)
Assigned to The Florida International University Board of Trustees, Miami, FL (US)
Filed by Raphael G. Raptis, Miami, FL (US); Indranil Chakraborty, Miami, FL (US); and Shambhu Kandel, Miami, FL (US)
Filed on Oct. 9, 2023, as Appl. No. 18/378,009.
Application 18/378,009 is a division of application No. 17/513,990, filed on Oct. 29, 2021, granted, now 11,779,598.
Application 17/513,990 is a continuation of application No. 16/932,075, filed on Jul. 17, 2020, granted, now 11,160,829, issued on Nov. 2, 2021.
Application 16/932,075 is a continuation of application No. 16/456,834, filed on Jun. 28, 2019, granted, now 10,828,327, issued on Nov. 10, 2020.
Claims priority of provisional application 62/722,664, filed on Aug. 24, 2018.
Prior Publication US 2024/0050469 A1, Feb. 15, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 33/38 (2006.01); A61P 31/04 (2006.01); C07F 1/00 (2006.01); C07F 9/6584 (2006.01)
CPC A61K 33/38 (2013.01) [A61P 31/04 (2018.01); C07F 1/005 (2013.01); C07F 9/65848 (2013.01)] 6 Claims
OG exemplary drawing
 
1. A method of synthesizing a dinuclear silver (I) pyrazolido complex, the method comprising the steps of:
providing silver oxide (Ag2O) or AgL precursor; wherein AgL is selected from the group consisting of silver acetate, silver benzoate, silver trifluorosulfonate, silver nitrate, and silver chloride;
providing a pyrazole derivative, wherein the pyrazole derivative comprises independent substituents at R3, R4, and R5 selected from the group consisting of hydrogen, halogen, hydroxyl, nitro, alkyl, alkenyl, aryl, formyl, acetyl, halogen substituted alkyl, halogen substituted aryl, halogen substituted sulfuryl, imine-linked PTA, amine-linked PTA, imine-linked adamantane, amine-linked adamantine, imine-linked triphenylphosphine, and amine-linked triphenylphosphine;
reacting the pyrazole derivative with the silver oxide or silver precursor in equimolar ratios at ambient conditions to generate a polymer having a general formula of [Ag(pz*)]n, wherein pz* is a substituted pyrazolido anion; optionally, purifying said polymer; and
reacting the polymer with a phosphine selected from the group consisting of phosphaadamantane (PA), phenanthrene diphenylphosphine (PDPP), 8-((4-phosphino)phenyl)-4,4-dimethyl-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene (PMBODIPY), 8-((4-phosphino) phenyl)-4,4-diethyl-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene (PEBODIPY), and 8-((4-phosphino) phenyl)-4,4-diphenyl-1,3,5,7-tetramethyl-2,6-diethyl-4-bora-3a,4a-diaza-s-indacene (PPBODIPY).