US 12,251,373 B2
Compounds and methods of treating retinal degeneration
Krzysztof Palczewski, Ivrine, CA (US); and Yuanyuan Chen, Pittsburgh, PA (US)
Assigned to CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US); and UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US)
Filed by CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US); and UNIVERSITY OF PITTSBURGH—OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION, Pittsburgh, PA (US)
Filed on Sep. 5, 2023, as Appl. No. 18/461,023.
Application 18/461,023 is a continuation of application No. 17/544,454, filed on Dec. 7, 2021, granted, now 11,744,826, issued on Sep. 5, 2023.
Application 17/544,454 is a continuation of application No. 16/609,162, granted, now 11,191,752, previously published as PCT/US2018/030251, filed on Apr. 30, 2018.
Claims priority of provisional application 62/645,576, filed on Mar. 20, 2018.
Claims priority of provisional application 62/491,811, filed on Apr. 28, 2017.
Prior Publication US 2024/0041847 A1, Feb. 8, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/4402 (2006.01); A61K 31/365 (2006.01); A61K 31/381 (2006.01); A61P 29/00 (2006.01)
CPC A61K 31/4402 (2013.01) [A61K 31/365 (2013.01); A61K 31/381 (2013.01); A61P 29/00 (2018.01)] 5 Claims
 
1. A compound having formula (I);

OG Complex Work Unit Chemistry
wherein X1 is CH2, C═O, or N—R3;
wherein X2 is O or N—R4;
wherein at least one of X1 is not N—R3 or X2 is not N—R4;
wherein R1 and R2 are each independently selected from the group consisting of hydrogen, a substituted or unsubstituted cycloalkyl, heterocyclyl, aryl, and heteroaryl, wherein at least one of R1 or R2 is a substituted or unsubstituted thiophene;
wherein R3 and R4 are each independently selected from the group consisting of hydrogen, a substituted or unsubstituted C1-C24 alkyl, C2-C24 alkenyl, C2-C24 alkynyl, C3-C20 aryl, heteroaryl, heterocycloalkenyl containing from 5-6 ring atoms (wherein from 1-3 of the ring atoms is independently selected from N, NH, N(C1-C6 alkyl), NC(O)(C1-C6 alkyl), O, and S), C6-C24 alkaryl, C6-C24 aralkyl, halo, —Si(C1-C3 alkyl)3, hydroxyl, sulfhydryl, C1-C24 alkoxy, C2-C24 alkenyloxy, C2-C24 alkynyloxy, C5-C20 aryloxy, acyl, acyloxy, C2-C24 alkoxycarbonyl, C6-C20 aryloxycarbonyl, C2-C24 alkylcarbonato, C6-C20 arylcarbonato, carboxy, carboxylato, carbamoyl, C1-C24 alkyl-carbamoyl, arylcarbamoyl, thiocarbamoyl, carbamido, cyano, isocyano, cyanato, isocyanato, isothiocyanato, azido, formyl, thioformyl, amino, C1-C24 alkyl amino, C5-C20 aryl amino, C2-C24 alkylamido, C6-C20 arylamido, imino, alkylimino, arylimino, nitro, nitroso, sulfo, sulfonato, C1-C24 alkylsulfanyl, arylsulfanyl, C1-C24 alkylsulfinyl, C5-C20 arylsulfinyl, C1-C24 alkylsulfonyl, C5-C20 arylsulfonyl, phosphono, phosphonato, phosphinato, phospho, or phosphino or combinations thereof;
and pharmaceutically acceptable salts thereof.