| CPC A61B 6/547 (2013.01) [A61B 6/4441 (2013.01); A61B 6/469 (2013.01); A61B 6/505 (2013.01); G06T 7/11 (2017.01); G06T 7/33 (2017.01); G06T 7/73 (2017.01); G06T 2200/04 (2013.01); G06T 2207/10116 (2013.01); G06T 2207/20104 (2013.01); G06T 2207/30012 (2013.01)] | 16 Claims |

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1. A system for positioning of an X-ray imaging system, the system comprising:
a processor in communication with memory, the processor configured to:
obtain three-dimensional (3D) image data of a spine region of interest of a subject comprising a spine structure;
select at least one vertebra of the spine structure as target vertebra;
segment the target vertebra in the 3D image data to identify at least one anatomic feature of the target vertebra, wherein the at least one anatomic feature includes end plates of the at least one vertebra;
define a position of a predetermined reference line based on a spatial arrangement of the at least one identified anatomic feature, wherein the predetermined reference line is defined as a line running between a pair of pedicle portions of the at least one vertebra, through a spinous process between the end plates, and parallel to surfaces of the end plates;
determine a target viewing direction of an X-ray imaging system with respect to the position of the predetermined reference line; and
provide the target viewing direction for the X-ray imaging system; and
the X-ray imaging system with an X-ray source and an X-ray detector, the X-ray imaging system configured to acquire X-ray images of an anatomy of the subject,
wherein the X-ray source, together with the X-ray detector, and the subject are movable in relation to each other, and
wherein the X-ray source, together with the X-ray detector, and the subject are movable according to the target viewing direction determined by the processor for positioning of the X-ray imaging system.
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