US 12,251,239 B2
System and method of assessing intra-arterial fluid volume using intelligent pulse averaging with integrated EKG and PPG sensors
Eric Raman, Seattle, WA (US); Kevin Peterson, Mountain View, CA (US); and Iain Hueton, Salt Lake City, UT (US)
Assigned to HEMOCEPT INC., Seattle, WA (US)
Filed by HEMOCEPT INC., Seattle, WA (US)
Filed on Oct. 30, 2023, as Appl. No. 18/385,294.
Application 18/385,294 is a continuation of application No. 17/229,741, filed on Apr. 13, 2021, granted, now 11,801,016.
Application 17/229,741 is a continuation of application No. 17/135,936, filed on Dec. 28, 2020.
Claims priority of provisional application 63/067,147, filed on Aug. 18, 2020.
Claims priority of provisional application 63/009,470, filed on Apr. 14, 2020.
Prior Publication US 2024/0130692 A1, Apr. 25, 2024
Prior Publication US 2024/0225562 A9, Jul. 11, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/00 (2006.01); A61B 5/0205 (2006.01); A61B 5/022 (2006.01); A61B 5/024 (2006.01); A61B 5/0245 (2006.01); A61B 5/145 (2006.01); A61B 5/1455 (2006.01); A61B 5/282 (2021.01); A61B 5/349 (2021.01); A61B 5/366 (2021.01); G16H 40/63 (2018.01)
CPC A61B 5/7285 (2013.01) [A61B 5/0006 (2013.01); A61B 5/0036 (2018.08); A61B 5/004 (2013.01); A61B 5/0205 (2013.01); A61B 5/024 (2013.01); A61B 5/14 (2013.01); A61B 5/14552 (2013.01); A61B 5/282 (2021.01); A61B 5/349 (2021.01); A61B 5/366 (2021.01); A61B 5/4839 (2013.01); A61B 5/6823 (2013.01); A61B 5/6831 (2013.01); A61B 5/6833 (2013.01); G16H 40/63 (2018.01); A61B 5/02427 (2013.01); A61B 5/0245 (2013.01); A61B 2560/0223 (2013.01); A61B 2562/146 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A computer logic system for and analyzing a PPG signal and an EKG signal, wherein the computer logic system is configured to:
obtain (a) the PPG signal from a device that includes at least on PPG sensor mounted thereon for measuring the person's PPG signal at multiple wavelengths of light, and (b) the EKG signal from a plurality of electrodes configured to be attached to the person;
segment the PPG signal into a series of PPG signal segments based upon features in the identified cardiac cycles,
sort the PPG signal segments into a plurality of bins, wherein a first set of PPG signal segments are sorted into a first plurality of bins based upon a similarity in durations of prior R-to-R cardiac cycles, and a second set of PPG signal segments are sorted into a second plurality of bins based upon a similarity in durations of prior-prior R-to-R cardiac cycles,
generate a composite signal for each of the first and second pluralities of bins comprising a system for summing or averaging the PPG signal segments in the bin,
generate a composite Signal Prime Over Signal (SPOS) for each of the composite signals comprising a system for calculating a derivative of the composite signal and normalizing the derivative of the composite signal by the composite signal itself,
measure a person's relative hydration level by detecting a change in the shape of at least one of the composite SPOS generated from the first plurality of bins and the composite SPOS generated from the second plurality of bins; and
output to a display device a treatment recommendation based on the person's relative hydration level, wherein the treatment recommendation is at least of a positional change, giving further fluid, holding fluid, removing fluid, or giving diuretics.