US 12,251,150 B2
Neuromodulation cryotherapeutic devices and associated systems and methods
Naomi Buckley, Galway (IE); Benjamin J Clark, Redwood City, CA (US); Michael Cummins, Roscam (IE); Danny Donovan, Galway (IE); Mark Gelfand, New York, NY (US); Luke Hughes, Galway (IE); Brian Kelly, Galway (IE); Gary Kelly, Windsor, CA (US); Grace Kelly, Clifden (IE); John Kelly, Ballinsloe (IE); Mark S. Leung, Shawnigan Lake (CA); Gwenda Francis, Ballybrit (IE); Barry Mullins, County Wicklow (IE); Karun D. Naga, Los Altos, CA (US); Stephen Nash, Galway (IE); Eric Ryba, Durango, CO (US); Fiachra Sweeney, Galway (IE); Vincenzo Tilotta, Galway (IE); Roman Turovskiy, San Francisco, CA (US); Lana Woolley, Galway (IE); Denise Zarins, Saratoga, CA (US); and Michael Turovskiy, East Palo Alto, CA (US)
Assigned to Medtronic Ardian Luxembourg S.a.r.l., Luxembourg (LU)
Filed by Medtronic Ardian Luxembourg S.a.r.l., Luxembourg (LU)
Filed on Nov. 16, 2020, as Appl. No. 17/099,465.
Application 17/099,465 is a continuation of application No. 16/221,174, filed on Dec. 14, 2018, granted, now 10,842,547.
Application 16/221,174 is a continuation of application No. 15/229,761, filed on Aug. 5, 2016, granted, now 10,188,445, issued on Jan. 29, 2019.
Application 15/229,761 is a continuation of application No. 13/279,326, filed on Oct. 23, 2011, granted, now 9,439,708, issued on Sep. 13, 2016.
Claims priority of provisional application 61/546,510, filed on Oct. 12, 2011.
Claims priority of provisional application 61/528,684, filed on Aug. 29, 2011.
Claims priority of provisional application 61/528,091, filed on Aug. 26, 2011.
Claims priority of provisional application 61/406,968, filed on Oct. 26, 2010.
Prior Publication US 2021/0068886 A1, Mar. 11, 2021
Int. Cl. A61B 18/02 (2006.01); A61B 17/22 (2006.01); A61B 18/00 (2006.01)
CPC A61B 18/02 (2013.01) [A61B 2017/22054 (2013.01); A61B 2017/22067 (2013.01); A61B 2018/00023 (2013.01); A61B 2018/00166 (2013.01); A61B 2018/0022 (2013.01); A61B 2018/00232 (2013.01); A61B 2018/0025 (2013.01); A61B 2018/00261 (2013.01); A61B 2018/00404 (2013.01); A61B 2018/00434 (2013.01); A61B 2018/00511 (2013.01); A61B 2018/00577 (2013.01); A61B 2018/0212 (2013.01); A61B 2018/0262 (2013.01); A61B 2018/0268 (2013.01)] 18 Claims
OG exemplary drawing
 
1. A cryotherapeutic system, comprising:
a cryotherapeutic device including:
an elongated shaft with a distal end portion that is configured to locate the distal end portion intravascularly at a treatment site within a renal artery or renal ostium,
a cooling assembly positioned at the distal end portion of the elongated shaft and including an applicator with an expandable element, the expandable element including an inner expandable element having orifices, the inner expandable element configured to distribute a refrigerant to the expandable element via the orifices,
wherein the expandable element includes a raised helical portion positioned around a recessed portion with the expandable element in an expanded state,
a pressure sensor configured to detect a pressure within the expandable element,
a pressure line fluidly coupling a pressure monitoring lumen and the pressure sensor, the pressure monitoring lumen extending through the elongated shaft and having a distal opening in fluid communication with the expandable element; and
a console coupled to the cryotherapeutic device and including:
a refrigerant supply container that is configured to retain the refrigerant and is coupled to a supply line that is configured to transport the refrigerant to the cryotherapeutic device,
an adaptor configured to removably couple the pressure line to the console such that the pressure line is removable from the console, and
a controller configured to:
determine whether the pressure sensor is calibrated; and
control a flow of the refrigerant to the cryotherapeutic device based on the pressure in response to determining that the pressure sensor is calibrated.