CPC C12P 21/005 (2013.01) [A61K 39/395 (2013.01); A61K 39/3955 (2013.01); A61K 39/40 (2013.01); C07K 16/12 (2013.01); C07K 16/1278 (2013.01); C07K 16/1282 (2013.01); C07K 16/18 (2013.01); C07K 16/26 (2013.01); C07K 16/28 (2013.01); C07K 16/2809 (2013.01); C07K 16/283 (2013.01); C07K 16/2866 (2013.01); C07K 16/2896 (2013.01); C07K 16/36 (2013.01); C07K 16/468 (2013.01); A61K 2039/507 (2013.01); C07K 2317/14 (2013.01); C07K 2317/31 (2013.01); C07K 2317/526 (2013.01); C07K 2317/56 (2013.01); C07K 2317/94 (2013.01)] | 7 Claims |
1. A heterodimeric antibody comprising a first human CH3 domain comprising a positively charged amino acid residue at position 364 according to the EU numbering system, and a second human CH3 domain comprising a negatively charged amino acid residue at position 368 according to the EU numbering system.
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