US 11,926,810 B2
Bioreactor with scaffolds
Zongsen Wang, Princeton, NJ (US); Wing Lau, Basking Ridge, NJ (US); Faribourz Payvandi, Belle Mead, NJ (US); Peng Yue, Vista, CA (US); Azadeh Jadali, Coram, NY (US); and Peter Materna, Metuchen, NJ (US)
Assigned to 3D Biotek, LLC, Warren, NJ (US)
Filed by 3D BIOTEK, LLC, Warren, NJ (US)
Filed on Dec. 6, 2022, as Appl. No. 18/076,203.
Application 18/076,203 is a continuation of application No. 16/863,220, filed on Apr. 30, 2020, granted, now 11,566,215.
Application 16/863,220 is a continuation of application No. 15/686,211, filed on Aug. 25, 2017, abandoned.
Claims priority of provisional application 62/380,414, filed on Aug. 27, 2016.
Prior Publication US 2023/0112777 A1, Apr. 13, 2023
Int. Cl. C12M 1/00 (2006.01); C12M 1/02 (2006.01); C12M 1/06 (2006.01); C12M 1/12 (2006.01); C12M 3/00 (2006.01)
CPC C12M 23/34 (2013.01) [C12M 21/08 (2013.01); C12M 23/40 (2013.01); C12M 25/02 (2013.01); C12M 25/14 (2013.01); C12M 27/00 (2013.01); C12M 27/02 (2013.01); C12M 29/10 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A bioreactor, comprising:
a reservoir container for holding a liquid medium;
a duct providing a flowpath in a generally vertical direction upward from said reservoir container from a lower end of said duct to an upper end of said duct;
a plurality of fiber assemblies located within said duct, a top of said duct being at a higher elevation than a top of said plurality of fiber assemblies; and
a circulation system for causing said liquid medium to flow upwardly through said duct past or through said plurality of fiber assemblies;
wherein said upper end of said duct comprises an overflow wall surrounded on its outside by a moat, a bottom of said moat being at a lower elevation than said top of said overflow wall, said upper end of said duct and said moat being in contact with a pocket region, said pocket region being bounded by a structure that is connected to said duct, said pocket region being isolated from fluid communication with an exterior of said pocket region;
wherein when said circulation system is operating, said liquid medium flows over said overflow wall within said pocket region and said liquid medium is in contact with gas that is contained in said pocket region, and said liquid medium overflows into said moat and is removed from said moat by said circulation system.