CPC C07D 491/107 (2013.01) [A61P 31/14 (2018.01); C07D 207/12 (2013.01); C07D 211/42 (2013.01); C07D 211/46 (2013.01); C07D 239/30 (2013.01); C07D 241/08 (2013.01); C07D 265/30 (2013.01); C07D 267/10 (2013.01); C07D 491/048 (2013.01); C07D 498/18 (2013.01)] | 35 Claims |
1. A compound having the structure of Formula (1):
or a pharmaceutically acceptable salt thereof, wherein,
R1 is selected from C1-4 alkanediyl, C1-4 heteroalkanediyl, substituted C1-4 alkanediyl, and substituted C1-4 heteroalkanediyl; and
R2 is a moiety having the structure of Formula (2d):
wherein,
each n is independently selected from, 1, 2, 3, and 4;
each A1 and A2 is independently selected from —CH2—, —CH(—R5)—, and —C(═O)—, wherein, each R5 is independently selected from —OH, —NH2, —NO2, C1-6 alkyl, C1-6 cycloalkyl, C6 aryl, C1-6 heteroalkyl, C1-6 heterocycloalkyl, C5-6 heteroaryl, substituted C1-6 alkyl, substituted C1-6 cycloalkyl, substituted C6 aryl, substituted C1-6 heteroalkyl, substituted C1-6 heterocycloalkyl, and substituted C5-6 heteroaryl;
one or more of A1 and A2 is independently selected from —CH(—R5)— and —C(═O)—; and
X is selected from CH(—OH)— and —SO2—.
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